ArticleJournal of virology1999
Depletion of blood-borne macrophages does not reduce demyelination in mice infected with a neurotropic coronavirus.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Prior murine neurotropic coronavirus infection ameliorates experimental autoimmune encephalitis.Journal of autoimmunity · 2026Article
- Trem2 deficiency impairs recovery and phagocytosis and dysregulates myeloid gene expression during virus-induced demyelination.Journal of neuroinflammation · 2022Article
- Microglia depletion exacerbates demyelination and impairs remyelination in a neurotropic coronavirus infection.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- KIR2DL4-HLAG interaction at human NK cell-oligodendrocyte interfaces regulates IFN-γ-mediated effects.Molecular immunology · 2019Article
- Microglia are required for protection against lethal coronavirus encephalitis in mice.The Journal of clinical investigation · 2018Article
- Distinct Gene Profiles of Bone Marrow-Derived Macrophages and Microglia During Neurotropic Coronavirus-Induced Demyelination.Frontiers in immunology · 2018Article
- Virus-induced inflammasome activation is suppressed by prostaglandin DProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Self-reactive CD4(+) T cells activated during viral-induced demyelination do not prevent clinical recovery.Journal of neuroinflammation · 2015Article
- Article
- Immune responses to non-tumor antigens in the central nervous system.Frontiers in oncology · 2014Review
- Review
- Analysis of the host transcriptome from demyelinating spinal cord of murine coronavirus-infected mice.PloS one · 2013Article
- Virally expressed interleukin-10 ameliorates acute encephalomyelitis and chronic demyelination in coronavirus-infected mice.Journal of virology · 2011Article
- Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Regulatory T cells inhibit T cell proliferation and decrease demyelination in mice chronically infected with a coronavirus.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- The pathogenesis of murine coronavirus infection of the central nervous system.Critical reviews in immunology · 2010Review
- The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous System.Current immunology reviews · 2009Article
- Role of IFN-gamma responsiveness in CD8 T-cell-mediated viral clearance and demyelination in coronavirus-infected mice.Journal of neuroimmunology · 2008Article
- The spike glycoprotein of murine coronavirus MHV-JHM mediates receptor-independent infection and spread in the central nervous systems of Ceacam1a-/- Mice.Journal of virology · 2008Article
- Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM.Immunologic research · 2007Review
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Mice infected with the neurotropic coronavirus mouse hepatitis virus strain JHM (MHV-JHM) develop a chronic demyelinating disease with symptoms of hindlimb paralysis. Histological examination of the brains and spinal cords of these animals reveals the presence of large numbers of activated macrophages/microglia. In two other experimental models of demyelination, experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis virus-induced demyelination, depletion of hematogenous macrophages abrogates the demyelinating process. In both of these diseases, early events in the demyelinating process are inhibited by macrophage depletion. From these studies, it was not possible to determine whether infiltrating macrophages were required for late steps in the process, such as myelin removal. In this study, we show that when macrophages are depleted with either unmodified or mannosylated liposomes encapsulating dichloromethylene diphosphate, the amount of demyelination detected in MHV-infected mice is not affected. At a time when these cells were completely depleted from the liver, approximately equivalent numbers of macrophages were present in the spinal cords of control and drug-treated animals. These results suggest that blood-borne macrophages are not required for MHV-induced demyelination and also suggest that other cells, such as perivascular macrophages or microglia, perform the function of these cells in the presence of drug.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.