ArticleJournal of virology1999
Numerous length polymorphisms at short tandem repeats in human cytomegalovirus.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
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- Genome-wide identification and characterization of microsatellite markers within the Avipoxviruses.3 Biotech · 2022Article
- Global distribution of white spot syndrome virus genotypes determined using a novel genotyping assay.Archives of virology · 2019Article
- High-throughput analysis of human cytomegalovirus genome diversity highlights the widespread occurrence of gene-disrupting mutations and pervasive recombination.Journal of virology · 2015Article
- Complete genome analysis of a frog virus 3 (FV3) isolate and sequence comparison with isolates of differing levels of virulence.Virology journal · 2014Article
- Genotyping of a microsatellite locus to differentiate clinical Ostreid herpesvirus 1 specimens.Veterinary research · 2014Article
- Molecular characterization of herpes simplex virus 2 strains by analysis of microsatellite polymorphism.Journal of clinical microbiology · 2013Article
- Identifying the viral genes encoding envelope glycoproteins for differentiation of Cyprinid herpesvirus 3 isolates.Viruses · 2013Article
- Analysis of enzymatic digestion pattern of two open reading frames of Varciella-Zoster genome from Kuwaiti patients using the RFLP technique.Iranian journal of microbiology · 2012Article
- Differential distribution and occurrence of simple sequence repeats in diverse geminivirus genomes.Virus genes · 2012Article
- Adenovirus microsatellite reveals dynamics of transmission during a recent epidemic of human adenovirus serotype 14 infection.Journal of clinical microbiology · 2009Article
- Utilization of microsatellite polymorphism for differentiating herpes simplex virus type 1 strains.Journal of clinical microbiology · 2009Article
- Polymorphisms in the repeat long regions of oncogenic and attenuated pathotypes of Marek's disease virus 1.Virus genes · 2007Article
- Abundance, composition and distribution of simple sequence repeats and dinucleotide compositional bias within WSSV genomes.Journal of genetics · 2007Article
- Identifying and quantifying genotypes in polyclonal infections due to single species.Emerging infectious diseases · 2006Article
- Global identification of three major genotypes of varicella-zoster virus: longitudinal clustering and strategies for genotyping.Journal of virology · 2004Article
- Phylogenetic analysis of varicella-zoster virus: evidence of intercontinental spread of genotypes and recombination.Journal of virology · 2002Article
- Characterization of human cytomegalovirus strains by analysis of short tandem repeat polymorphisms.Journal of clinical microbiology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
We show the presence of numerous short tandem repeats in the human cytomegalovirus (HCMV) genome and assess their usefulness as molecular markers. The genome is shown to contain at least 24 microsatellite regions that exhibit length polymorphisms. Insertion-deletion polymorphisms at these short tandem repeats are common (80% of repeats examined are polymorphic among two laboratory strains and 10 clinical isolates). This is the first report of widespread microsatellite length polymorphism in a viral genome. Some regions are highly polymorphic: one was revealed by DNA sequencing to contain length variants at five closely linked sites, which combined resulted in 10 variants for this region among the 12 strains and isolates examined. This study not only provides a new molecular marker system for this virus but also extends our understanding of microsatellite polymorphism in two important ways. First, variable-length repeats in HCMV can be considerably shorter than polymorphic repeats previously found in other organisms. Second, highly variable microsatellite repeats are not confined to prokaryotes and eukaryotes, as previously assumed. This variation provides a useful marker system for distinguishing viral isolates, and similar markers are also likely to be found in other large-genome DNA viruses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.