ArticlePlant physiology1999
Heavy-metal regulation of thioredoxin gene expression in chlamydomonas reinhardtii
Article in Plant physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 82 citations in OpenAlex.
- Heavy metal-induced stress in eukaryotic algae-mechanisms of heavy metal toxicity and tolerance with particular emphasis on oxidative stress in exposed cells and the role of antioxidant response.Environmental science and pollution research international · 2022Review
- Transcriptome Analysis and Expression Profiling of Molecular Responses to Cd Toxicity inMycobiology · 2021Article
- Copper-induced concomitant increases in photosynthesis, respiration, and C, N and S assimilation revealed by transcriptomic analyses in Ulva compressa (Chlorophyta).BMC plant biology · 2020Article
- Article
- Genetic Engineering: A Promising Tool to Engender Physiological, Biochemical, and Molecular Stress Resilience in Green Microalgae.Frontiers in plant science · 2016Review
- Comprehensive Transcriptome Analysis of Response to Nickel Stress in White Birch (Betula papyrifera).PloS one · 2016Article
- Activation of Autophagy by Metals in Chlamydomonas reinhardtii.Eukaryotic cell · 2015Article
- Article
- Identification of copper-induced genes in the marine alga Ulva compressa (Chlorophyta).Marine biotechnology (New York, N.Y.) · 2011Article
- RNA-seq analysis of sulfur-deprived Chlamydomonas cells reveals aspects of acclimation critical for cell survival.The Plant cell · 2010Article
- TvDim1 of Trichoderma virens is involved in redox-processes and confers resistance to oxidative stresses.Current genetics · 2010Article
- Cadmium response and redoxin targets in Chlamydomonas reinhardtii: a proteomic approach.Photosynthesis research · 2006Article
- Functional specialization of Chlamydomonas reinhardtii cytosolic thioredoxin h1 in the response to alkylation-induced DNA damage.Eukaryotic cell · 2005Article
- Identification and analysis of safener-inducible expressed sequence tags in Populus using a cDNA microarray.Planta · 2004Article
- The Arabidopsis cytosolic thioredoxin h5 gene induction by oxidative stress and its W-box-mediated response to pathogen elicitor.Plant physiology · 2004Article
- The thioredoxin superfamily in Chlamydomonas reinhardtii.Photosynthesis research · 2004Article
- Chlamydomonas reinhardtii as a eukaryotic photosynthetic model for studies of heavy metal homeostasis and tolerance.The New phytologist · 2003Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heavy metals are highly toxic compounds for cells. In this report we demonstrate that the expression of Chlamydomonas reinhardtii thioredoxins (TRX) m and h is induced by heavy metals. Upon exposure of the cells to Cd and Hg, a strong accumulation of both messengers was observed. Western-blot experiments revealed that among these two TRXs, only TRX h polypeptides accumulated in response to the toxic cations. A biochemical analysis indicated that heavy metals inhibit TRX activity, presumably by binding at the level of their active site. Sequence analysis of the C. reinhardtii TRX h promoter revealed the presence of cis-acting elements related to cadmium induction. The origins and purposes of this regulation are discussed. Our data suggest, for the first time to our knowledge, a possible implication of TRXs in defense mechanisms against heavy metals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.