ReviewClinical microbiology reviews1999
Pathogenesis of onchocercal keratitis (River blindness).
Review in Clinical microbiology reviews, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 128 citations in OpenAlex.
- Onchocerciasis overview: pathogenesis, clinical spectrum, and therapeutic challenges of a neglected tropical disease.Frontiers in parasitology · 2026Review
- Programmed cell death pathways as targets for developing antifilarial drugs: Lessons from the recent findings.Journal of cellular and molecular medicine · 2023Review
- Preliminary assessment ofParasite epidemiology and control · 2023Article
- Eosinophils in filarial infections: Inducers of protection or pathology?Frontiers in immunology · 2022Review
- Neuroimmunology of Common Parasitic Infections in Africa.Frontiers in immunology · 2022Review
- How does onchocerciasis-related skin and eye disease in Africa depend on cumulative exposure to infection and mass treatment?PLoS neglected tropical diseases · 2021Article
- MicroRNAs in Ocular Infection.Microorganisms · 2019Review
- Prediction and validation of the structural features of Ov58GPCR, an immunogenic determinant of Onchocerca volvulus.PloS one · 2018Article
- O-5S quantitative real-time PCR: a new diagnostic tool for laboratory confirmation of human onchocerciasis.Parasites & vectors · 2017Article
- Significant heterogeneity in Wolbachia copy number within and between populations of Onchocerca volvulus.Parasites & vectors · 2017Article
- Experimental Models to Study the Role of Microbes in Host-Parasite Interactions.Frontiers in microbiology · 2016Review
- Modelling the impact of ivermectin on River Blindness and its burden of morbidity and mortality in African Savannah: EpiOncho projections.Parasites & vectors · 2014Article
- Ocular onchocerciasis in the Yanomami communities from Brazilian Amazon: effects on intraocular pressure.The American journal of tropical medicine and hygiene · 2014Article
- Targeting toll-like receptor signaling as a novel approach to prevent ocular infectious diseases.The Indian journal of medical research · 2013Review
- Wolbachia heat shock protein 60 induces pro-inflammatory cytokines and apoptosis in monocytes in vitro.Microbes and infection · 2012Article
- Density-dependent mortality of the human host in onchocerciasis: relationships between microfilarial load and excess mortality.PLoS neglected tropical diseases · 2012Article
- Granulocytes in helminth infection -- who is calling the shots?Current medicinal chemistry · 2012Review
- MyD88-deficient mice exhibit decreased parasite-induced immune responses but reduced disease severity in a murine model of neurocysticercosis.Infection and immunity · 2009Article
- Polymicrobial keratitis: Acanthamoeba and infectious crystalline keratopathy.American journal of ophthalmology · 2009Article
- River blindness: a success story under threat?PLoS medicine · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Onchocerciasis is a major cause of blindness. Although the World Health Organization has been successful in reducing onchocerciasis as a public health problem in parts of West Africa, there remain an estimated 17 million people infected with Onchocerca volvulus, the parasite that causes this disease. Ocular pathology can be manifested in any part of the eye, although disease manifestations are frequently characterized as either posterior or anterior eye disease. This review focuses on onchocerca-mediated keratitis that results from an inflammatory response in the anterior portion of the eye and summarizes what is currently known about human disease. This review also describes studies with experimental models that have been established to determine the immunological mechanisms underlying interstitial keratitis. The pathogenesis of keratitis is thought to be due to the host inflammatory response to degenerating parasites in the eye; therefore, the primary clinical symptoms of onchocercal keratitis (corneal opacification and neovascularization) are induced after injection of soluble O. volvulus antigens into the corneal stroma. Experimental approaches have demonstrated an essential role for sensitized T helper cells and shown that cytokines can regulate the severity of keratitis by controlling recruitment of inflammatory cells into the cornea. Chemokines are also important in inflammatory cell recruitment to the cornea, and their role in onchocerciasis is being examined. Further understanding of the molecular basis of the development of onchocercal keratitis may lead to novel approaches to immunologically based intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.