ArticleMolecular biology of the cell1999
Saccharomyces cerevisiae MPS2 encodes a membrane protein localized at the spindle pole body and the nuclear envelope.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Dynamic movement of the Golgi unit and its glycosylation enzyme zones.Nature communications · 2024Article
- The N-terminus of Sfi1 and yeast centrin Cdc31 provide the assembly site for a new spindle pole body.The Journal of cell biology · 2021Article
- Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.Life science alliance · 2020Article
- Extranuclear Structural Components that Mediate Dynamic Chromosome Movements in Yeast Meiosis.Current biology : CB · 2020Article
- Telomere-led meiotic chromosome movements: recent update in structure and function.Nucleus (Austin, Tex.) · 2020Review
- Yeast centrosome components form a noncanonical LINC complex at the nuclear envelope insertion site.The Journal of cell biology · 2019Article
- Review
- A ternary membrane protein complex anchors the spindle pole body in the nuclear envelope in budding yeast.The Journal of biological chemistry · 2017Article
- LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- Article
- Lessons from yeast: the spindle pole body and the centrosome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin.Chromosoma · 2013Review
- Article
- Mitotic spindle form and function.Genetics · 2012Article
- Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle.The Journal of cell biology · 2011Article
- Centriole movements in mammalian epithelial cells during cytokinesis.BMC cell biology · 2010Article
- N-terminal regions of Mps1 kinase determine functional bifurcation.The Journal of cell biology · 2010Article
- Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections.The Journal of cell biology · 2009Review
- The SESA network links duplication of the yeast centrosome with the protein translation machinery.Genes & development · 2009Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The MPS2 (monopolar spindle two) gene is one of several genes required for the proper execution of spindle pole body (SPB) duplication in the budding yeast Saccharomyces cerevisiae (). We report here that the MPS2 gene encodes an essential 44-kDa protein with two putative coiled-coil regions and a hydrophobic sequence. Although MPS2 is required for normal mitotic growth, some null strains can survive; these survivors exhibit slow growth and abnormal ploidy. The MPS2 protein was tagged with nine copies of the myc epitope, and biochemical fractionation experiments show that it is an integral membrane protein. Visualization of a green fluorescent protein (GFP) Mps2p fusion protein in living cells and indirect immunofluorescence microscopy of 9xmyc-Mps2p revealed a perinuclear localization with one or two brighter foci of staining corresponding to the SPB. Additionally, immunoelectron microscopy shows that GFP-Mps2p localizes to the SPB. Our analysis suggests that Mps2p is required as a component of the SPB for insertion of the nascent SPB into the nuclear envelope.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.