ArticleMolecular biology of the cell1999
Mapmodulin, cytoplasmic dynein, and microtubules enhance the transport of mannose 6-phosphate receptors from endosomes to the trans-golgi network.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Nucleation and Dynamics of Golgi-derived Microtubules.Frontiers in neuroscience · 2015Review
- Cracking the ANP32 whips: important functions, unequal requirement, and hints at disease implications.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Article
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- Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells.Molecular & cellular proteomics : MCP · 2012Article
- Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Human molecular genetics · 2011Article
- Acidic nuclear phosphoprotein 32kDa (ANP32)B-deficient mouse reveals a hierarchy of ANP32 importance in mammalian development.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Cpd-1 null mice display a subtle neurological phenotype.PloS one · 2010Article
- A FAM21-containing WASH complex regulates retromer-dependent sorting.Developmental cell · 2009Article
- Article
- Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi.Molecular biology of the cell · 2009Article
- Functional diversification of the nematode mbd2/3 gene between Pristionchus pacificus and Caenorhabditis elegans.BMC genetics · 2007Article
- The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins.Protein science : a publication of the Protein Society · 2007Article
- Shiga toxin facilitates its retrograde transport by modifying microtubule dynamics.Molecular biology of the cell · 2006Article
- Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells.The Journal of biological chemistry · 2006Article
- The Anp32 family of proteins containing leucine-rich repeats.Cerebellum (London, England) · 2005Review
- Rab9 GTPase regulates late endosome size and requires effector interaction for its stability.Molecular biology of the cell · 2004Article
- Cytoplasmic dynein-dynactin complex is required for spermatid growth but not axoneme assembly in Drosophila.Molecular biology of the cell · 2004Article
- Generation and characterization of LANP/pp32 null mice.Molecular and cellular biology · 2004Article
- Anp32e (Cpd1) and related protein phosphatase 2 inhibitors.Cerebellum (London, England) · 2003Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Late endosomes and the Golgi complex maintain their cellular localizations by virtue of interactions with the microtubule-based cytoskeleton. We study the transport of mannose 6-phosphate receptors from late endosomes to the trans-Golgi network in vitro. We show here that this process is facilitated by microtubules and the microtubule-based motor cytoplasmic dynein; transport is inhibited by excess recombinant dynamitin or purified microtubule-associated proteins. Mapmodulin, a protein that interacts with the microtubule-associated proteins MAP2, MAP4, and tau, stimulates the microtubule- and dynein-dependent localization of Golgi complexes in semi-intact Chinese hamster ovary cells. The present study shows that mapmodulin also stimulates the initial rate with which mannose 6-phosphate receptors are transported from late endosomes to the trans-Golgi network in vitro. These findings represent the first indication that mapmodulin can stimulate a vesicle transport process, and they support a model in which the microtubule-based cytoskeleton enhances the efficiency of vesicle transport between membrane-bound compartments in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.