ArticleMolecular biology of the cell1999
Role of the box C/D motif in localization of small nucleolar RNAs to coiled bodies and nucleoli.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed, 133 citations in OpenAlex.
- A small nucleolar RNA dictates the structure and function of translating ribosomes in Leishmania.Nature communications · 2026Article
- Nuclear ribonucleoprotein condensates as platforms for gene expression regulation.Genes & genomics · 2025Review
- A guide to the biogenesis and functions of endogenous small non-coding RNAs in animals.Nature reviews. Molecular cell biology · 2025Review
- Coilin and Cajal bodies.Nucleus (Austin, Tex.) · 2023Review
- snR30/U17 Small Nucleolar Ribonucleoprotein: A Critical Player during Ribosome Biogenesis.Cells · 2020Review
- Fibrillarin Ribonuclease Activity is Dependent on the GAR Domain and Modulated by Phospholipids.Cells · 2020Article
- Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length.Molecular biology of the cell · 2019Article
- Activation of transcription enforces the formation of distinct nuclear bodies in zebrafish embryos.RNA biology · 2017Review
- RNA modification in Cajal bodies.RNA biology · 2017Review
- Assembly and trafficking of box C/D and H/ACA snoRNPs.RNA biology · 2017Review
- Review
- The Subcellular Localization and Functional Analysis of Fibrillarin2, a Nucleolar Protein in Nicotiana benthamiana.BioMed research international · 2016Article
- Targeting vertebrate intron-encoded box C/D 2'-O-methylation guide RNAs into the Cajal body.Nucleic acids research · 2014Article
- Article
- CRM1 plays a nuclear role in transporting snoRNPs to nucleoli in higher eukaryotes.Nucleus (Austin, Tex.) · 2012Review
- CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport.The EMBO journal · 2011Article
- Telomerase trafficking and assembly in Xenopus oocytes.Journal of cell science · 2010Article
- Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae.Molecular and cellular biology · 2008Article
- A compartmentalized phosphorylation/dephosphorylation system that regulates U snRNA export from the nucleus.Molecular and cellular biology · 2008Article
- The role of the plant nucleolus in pre-mRNA processing.Current topics in microbiology and immunology · 2008Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small nucleolar RNAs (snoRNAs) are a large family of eukaryotic RNAs that function within the nucleolus in the biogenesis of ribosomes. One major class of snoRNAs is the box C/D snoRNAs named for their conserved box C and box D sequence elements. We have investigated the involvement of cis-acting sequences and intranuclear structures in the localization of box C/D snoRNAs to the nucleolus by assaying the intranuclear distribution of fluorescently labeled U3, U8, and U14 snoRNAs injected into Xenopus oocyte nuclei. Analysis of an extensive panel of U3 RNA variants showed that the box C/D motif, comprised of box C', box D, and the 3' terminal stem of U3, is necessary and sufficient for the nucleolar localization of U3 snoRNA. Disruption of the elements of the box C/D motif of U8 and U14 snoRNAs also prevented nucleolar localization, indicating that all box C/D snoRNAs use a common nucleolar-targeting mechanism. Finally, we found that wild-type box C/D snoRNAs transiently associate with coiled bodies before they localize to nucleoli and that variant RNAs that lack an intact box C/D motif are detained within coiled bodies. These results suggest that coiled bodies play a role in the biogenesis and/or intranuclear transport of box C/D snoRNAs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.