ArticleProceedings of the National Academy of Sciences of the United States of America1999
Dichotomy between naïve and memory CD4(+) T cell responses to Fas engagement.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 84 citations in OpenAlex.
- Fas acts as a T cell co-stimulatory receptor via both death domain-independent and -dependent mechanisms.Cell death and differentiation · 2026Article
- Differentiation into an Effector Memory Phenotype Potentiates HIV-1 Latency Reversal in CD4Journal of virology · 2019Article
- Interleukin 7 up-regulates CD95 protein on CD4+ T cells by affecting mRNA alternative splicing: priming for a synergistic effect on HIV-1 reservoir maintenance.The Journal of biological chemistry · 2015Article
- The NF-κB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Life in the Fas lane: differential outcomes of Fas signaling.Cellular and molecular life sciences : CMLS · 2013Review
- Death receptor-ligand systems in cancer, cell death, and inflammation.Cold Spring Harbor perspectives in biology · 2013Review
- The role of apoptosis-induced proliferation for regeneration and cancer.Cold Spring Harbor perspectives in biology · 2012Review
- Caspase-3 is transiently activated without cell death during early antigen driven expansion of CD8(+) T cells in vivo.PloS one · 2010Article
- Fas ligand is required for the development of respiratory syncytial virus vaccine-enhanced disease.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals.Clinical and experimental immunology · 2009Article
- A novel juxtamembrane domain in tumor necrosis factor receptor superfamily molecules activates Rac1 and controls neurite growth.Molecular biology of the cell · 2008Article
- Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes.Journal of leukocyte biology · 2008Article
- Mutation in the Fas pathway impairs CD8+ T cell memory.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Cellular metabolism as a basis for immune privilege.Journal of immune based therapies and vaccines · 2006Article
- Sexual dimorphism in immune response genes as a function of puberty.BMC immunology · 2006Article
- Interleukin-7 signalling is sufficient to phenotypically and functionally prime human CD4 naive T cells.Immunology · 2005Article
- FADD adaptor in cancer.Medical immunology (London, England) · 2005Article
- The effects of chemotherapeutics on cellular metabolism and consequent immune recognition.Journal of immune based therapies and vaccines · 2004Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Engagement of Fas (APO-1, CD95), a member of the tumor necrosis factor receptor superfamily, can induce apoptotic cell death. However, Fas engagement also can costimulate lymphocyte proliferation. The physiologic regulation of these two outcomes is poorly understood. Here, we have used two systems, the first in vitro and the second in vivo, to demonstrate that naïve and memory CD4(+) T cells display dichotomous responses to Fas ligation. Naïve CD4(+) T cells (CD44(lo), CD45RB+, CD62L+) die as a consequence of Fas ligation in the presence of anti-CD3 antibody, whereas memory T cells (CD44(hi), CD45RB-, CD62L-), freshly isolated from the same starting population and subjected to the same stimulation conditions, are costimulated to proliferate by Fas ligation. In vitro, we demonstrate that CD28-mediated signals or T helper 1 and T helper 2 differentiation cytokines alter the response of naïve T cells, but not of memory T cells, to Fas ligation. In vivo experiments in hen egg lysozyme (HEL) T cell receptor transgenic mice show that CD4(+) T cells from HEL-naïve mice are killed by Fas ligation, but CD4(+) T cells from long-term HEL-exposed mice are costimulated by Fas ligation. Thus, the physiological outcome of Fas ligation in CD4(+) T cells is determined primarily by the antigenic history of the T cell.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.