ArticleProceedings of the National Academy of Sciences of the United States of America1999
IL-4 enhances proliferation and mediator release in mature human mast cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
- Context-dependent regulation of mast cell-mediated food allergy in C57BL/6J mice.The Journal of allergy and clinical immunology · 2026Article
- Food allergy: begin at the skin, end at the mast cell?Nature reviews. Immunology · 2025Review
- Review
- Biosynthetic pathway for leukotrienes is stimulated by lipopolysaccharide and cytokines in pig endometrial stromal cells.Scientific reports · 2025Article
- Retinoic Acid Regulates Allergic Inflammation via Limiting Mast Cell Activation.Food science & nutrition · 2025Article
- Targeting inhibition of the inflammatory response: advances in the treatment of myocardial fibrosis with natural medicine and active ingredients.Frontiers in cardiovascular medicine · 2025Review
- Thymic Stromal Lymphopoietin (TSLP): Evidence in Respiratory Epithelial-driven Diseases Including Chronic Rhinosinusitis with Nasal Polyps.Current allergy and asthma reports · 2024Review
- IL-10 Differentially Promotes Mast Cell Responsiveness to IL-33, Resulting in Enhancement of Type 2 Inflammation and Suppression of Neutrophilia.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology.Cells · 2024Article
- Article
- A new microphysiological system shows hypoxia primes human ISCs for interleukin-dependent rescue of stem cell activity.bioRxiv : the preprint server for biology · 2023Article
- How an Immune-Factor-Based Formulation of Micro-Immunotherapy Could Interfere with the Physiological Processes Involved in the Atopic March.International journal of molecular sciences · 2023Review
- Inhibition of Complex I of the Respiratory Chain, but Not Complex III, Attenuates Degranulation and Cytokine Secretion in Human Skin Mast Cells.International journal of molecular sciences · 2022Article
- Molecular Signaling and Transcriptional Regulation of Histamine HCurrent topics in behavioral neurosciences · 2022Review
- INSIGHTS INTO THE REGULATION OF MAST CELL FUNCTION IN TYPE 2 INFLAMMATION.Transactions of the American Clinical and Climatological Association · 2022Article
- Mast cell tissue heterogeneity and specificity of immune cell recruitment.Frontiers in immunology · 2022Review
- Utilizing mast cells in a positive manner to overcome inflammatory and allergic diseases.Frontiers in immunology · 2022Review
- Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro.Bioengineering (Basel, Switzerland) · 2021Article
- Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis.Journal of translational medicine · 2021Article
- The clinical significance of spondin 2 eccentric expression in peripheral blood mononuclear cells in bronchial asthma.Journal of clinical laboratory analysis · 2021Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue mast cells (MC) are recognized as key effector cells of immediate-type allergic reactions releasing inflammatory mediators and cytokines on stimulation with antigen, but they also might be involved in IgE-independent inflammatory and tissue repair processes. The mechanism of human MC regulation in tissue is not fully understood. Here, we show that IL-4, in synergy with stem cell factor (SCF), regulates the function of purified human MC isolated from intestinal tissue. Whereas SCF induced only marginal proliferation of MC cultured in vitro up to 4 weeks, addition of IL-4 and SCF strongly increased the proliferation rate. Moreover, IL-4, which by itself had no visible effect on human MC, enhanced the release of histamine, leukotriene C4, and IL-5 in MC triggered by IgE receptor crosslinking. The IL-4 effects occurred in a dose-dependent fashion (ED50 = 100 pg/ml) and could be totally blocked by a competitive IL-4 receptor antagonist. Our data indicate that IL-4 is an important regulator of human MC function and suggest that mature MC retain the capacity to proliferate in a particular tissue environment.
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