ArticleProceedings of the National Academy of Sciences of the United States of America1999
SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1).
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 114 citations in OpenAlex.
- Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to Limit Carcinogen-Induced Lung Adenocarcinoma.Cancer research · 2023Article
- mMolecular therapy. Nucleic acids · 2022Article
- Glyceraldehyde-3-phosphate Dehydrogenase is a Multifaceted Therapeutic Target.Pharmaceutics · 2020Review
- Blockade of AXL activation overcomes acquired resistance to EGFR tyrosine kinase inhibition in non-small cell lung cancer.Translational cancer research · 2019Article
- E3 ubiquitin ligase siah‑1 nuclear accumulation is critical for homocysteine‑induced impairment of C6 astroglioma cells.Molecular medicine reports · 2019Article
- Deciphering the Pharmacological Mechanism of the HerbFrontiers in pharmacology · 2019Article
- The E3 Ubiquitin Ligase Siah-1 Suppresses Avian Reovirus Infection by Targeting p10 for Degradation.Journal of virology · 2018Article
- Expression of RING Finger Protein 38 in Serotonergic Neurons in the Brain of Nile Tilapia,Frontiers in neuroanatomy · 2018Article
- RING Finger Protein 38 Is a Neuronal Protein in the Brain of Nile Tilapia,Frontiers in neuroanatomy · 2017Article
- E3 Ubiquitin Ligase Siah-1 is Down-regulated and Fails to Target Natural HBx Truncates for Degradation in Hepatocellular Carcinoma.Journal of Cancer · 2016Article
- High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1.The Journal of biological chemistry · 2015Article
- Article
- SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.Cell cycle (Georgetown, Tex.) · 2015Article
- Genomic DNA hypomethylation is associated with neural tube defects induced by methotrexate inhibition of folate metabolism.PloS one · 2015Article
- Structure-based design of covalent Siah inhibitors.Chemistry & biology · 2013Article
- Expression and clinical significance of SIAH in laryngeal squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2013Article
- Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1α (HIF-1α) during hypoxia.The Journal of biological chemistry · 2012Article
- Novel tumor suppressive function of Smad4 in serum starvation-induced cell death through PAK1-PUMA pathway.Cell death & disease · 2011Article
- Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1.Molecular and cellular biochemistry · 2011Article
- microRNA profiling in Epstein-Barr virus-associated B-cell lymphoma.Nucleic acids research · 2011Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously described biological model systems for studying tumor suppression in which, by using H-1 parvovirus as a selective agent, cells with a strongly suppressed malignant phenotype (KS or US) were derived from malignant cell lines (K562 or U937). By using cDNA display on the K562/KS cells, 15 cDNAs were now isolated, corresponding to genes differentially regulated in tumor suppression. Of these, TSAP9 corresponds to a TCP-1 chaperonin, TSAP13 to a regulatory proteasome subunit, and TSAP21 to syntaxin 11, a vesicular trafficking molecule. The 15 cDNAs were used as a molecular fingerprint in different tumor-suppression models. We found that a similar pattern of differential regulation is shared by activation of p53, p21(Waf1), and the human homologue of Drosophila seven in absentia, SIAH-1. Because SIAH-1 is differentially expressed in the various models, we characterized it at the protein and functional levels. The 32-kDa, mainly nuclear protein encoded by SIAH-1, can induce apoptosis and promote tumor suppression. These results suggest the existence of a common mechanism of tumor suppression and apoptosis shared by p53, p21(Waf1), and SIAH-1 and involving regulation of the cellular machinery responsible for protein folding, unfolding, and trafficking.
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