ArticleProceedings of the National Academy of Sciences of the United States of America1999
Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 85 citations in OpenAlex.
- Chromosome condensation mechanically primes the nucleus for mitosis.The EMBO journal · 2026Article
- A distinct phase of cyclin B (Cdc13) nuclear export at mitotic entry inOpen biology · 2025Article
- Nuclear Transport Receptor Importin-β Inhibition Enhances Cell Cycle Arrest Induced by CKS2 Knockdown to Suppress Neuroblastoma Progression.Neurochemical research · 2025Article
- M-Motif, a potential non-conventional NLS in YAP/TAZ and other cellular and viral proteins that inhibits classic protein import.iScience · 2025Article
- Article
- Cellular roadmaps of viroid infection.Trends in microbiology · 2023Review
- Targeting CDK1 in cancer: mechanisms and implications.NPJ precision oncology · 2023Review
- Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation.The Journal of cell biology · 2022Article
- Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M.Cellular and molecular life sciences : CMLS · 2018Article
- Unique Regulatory Mechanisms for the Human Embryonic Stem Cell Cycle.Journal of cellular physiology · 2017Review
- The G2 checkpoint-a node-based molecular switch.FEBS open bio · 2017Article
- The biochemistry of mitosis.Cold Spring Harbor perspectives in biology · 2015Review
- The function of importin β1 is conserved in eukaryotes but the substrates may vary in organisms.Plant signaling & behavior · 2013Article
- In the wrong place at the wrong time: does cyclin mislocalization drive oncogenic transformation?Nature reviews. Cancer · 2013Review
- In vitro growth inhibition of human cancer cells by novel honokiol analogs.Bioorganic & medicinal chemistry · 2012Article
- Nuclear import by karyopherin-βs: recognition and inhibition.Biochimica et biophysica acta · 2011Review
- HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention.Retrovirology · 2011Review
- Requirement for lamin B receptor and its regulation by importin {beta} and phosphorylation in nuclear envelope assembly during mitotic exit.The Journal of biological chemistry · 2010Article
- Involvement of importin-4 in the transport of transition protein 2 into the spermatid nucleus.Molecular and cellular biology · 2008Article
- 14-3-3 theta binding to cell cycle regulatory factors is enhanced by HIV-1 Vpr.Biology direct · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitosis is triggered in vertebrate cells by the cyclin B1-Cdc2 complex. The activation of this complex at the end of G2 phase is accompanied by its translocation from the cytoplasm to the nucleus. We used digitonin-permeabilized human cells to analyze the mechanism by which cyclin B1-Cdc2 is imported into the nucleus. Cyclin B1-Cdc2 import was not blocked by inhibitors of the importin alpha-dependent import pathway or by dominant negative versions of the GTPase Ran or importin beta. However, the rate of cyclin B1 import was decreased by immunodepletion of importin beta from cytosol. Purified importin beta promoted cyclin B1 import in the absence of cytosol or Ran and in the presence of the dominant negative Ran mutant. We conclude that cyclin B1 import is mediated by an unusual importin beta-dependent mechanism that does not require Ran.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.