ArticleProceedings of the National Academy of Sciences of the United States of America1999
Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 65 citations in OpenAlex.
- Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.The Journal of biological chemistry · 2016Article
- Article
- Circulating anti-filamin C autoantibody as a potential serum biomarker for low-grade gliomas.BMC cancer · 2014Article
- Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and γ-secretase independent redistribution.Journal of Alzheimer's disease : JAD · 2010Article
- Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Increased cell-cell adhesion, a novel effect of R-(-)-deprenyl.Journal of neural transmission (Vienna, Austria : 1996) · 2005Article
- Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space.American journal of physiology. Cell physiology · 2005Article
- The ins and outs of presenilin 1 membrane topology.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The presenilins turned inside out: implications for their structures and functions.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes.Molecular psychiatry · 2003Article
- Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.The Journal of cell biology · 2002Article
- A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.The EMBO journal · 2002Article
- gamma-Secretase inhibitors as molecular probes of presenilin function.Journal of molecular neuroscience : MN · 2001Review
- The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.The Journal of cell biology · 2001Article
- The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement.The Journal of cell biology · 2001Article
- Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons.The Journal of cell biology · 1999Article
- Closing in on the amyloid cascade: recent insights into the cell biology of Alzheimer's disease.Molecular neurobiologyReview
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Most familial early-onset Alzheimer's disease cases are caused by mutations in the presenilin 1 (PS1) gene. Subcellular localization of the endogenous PS1 is essential for understanding its function, interactions with proteins, and role in Alzheimer's disease. Although numerous studies revealed predominant localization of PS1 to endoplasmic reticulum and Golgi, there are conflicting reports on the localization of PS1 to the cell surface. We found that endogenous PS1 is highly expressed in T lymphocytes (Jurkat cells). Using a variety of methods, we present evidence that endogenous PS1 is localized to the cell surface in addition to intracellular membrane compartments. Moreover, PS1 appeared in high levels on the surface of lamellipodia upon adhesion of the cells to a collagen matrix. The redistribution of PS1 in adhered cells was strikingly similar to that of the well characterized adhesion protein CD44. Cell surface PS1 formed complexes in vivo with actin-binding protein filamin (ABP-280), which is known to form bridges between cell surface receptors and cytoskeleton and mediate cell adhesion and cell motility. Taken together, our results suggest a role of PS1 in cell adhesion and/or cell-matrix interaction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.