ArticleThe American journal of pathology1999
Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 143 citations in OpenAlex.
- B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin.Arthritis research & therapy · 2012Trial
- Investigating the therapeutic role of anlotinib in radiation-induced lung injury.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Effects of antifibrotic agent Nintedanib on experimentally generated priapism model in rats.World journal of urology · 2025Article
- Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis.Science translational medicine · 2023Article
- EGFR Signaling in Lung Fibrosis.Cells · 2022Review
- Targeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis.Frontiers in pharmacology · 2022Review
- Protein tyrosine phosphatase-α amplifies transforming growth factor-β-dependent profibrotic signaling in lung fibroblasts.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not.American journal of respiratory cell and molecular biology · 2018Review
- Blocking fibrotic signaling in fibroblasts from patients with carpal tunnel syndrome.Journal of cellular physiology · 2018Review
- PDGF signaling pathway in hepatic fibrosis pathogenesis and therapeutics (Review).Molecular medicine reports · 2017Review
- Dasatinib inhibits TGFβ-induced myofibroblast differentiation through Src-SRF Pathway.European journal of pharmacology · 2015Article
- Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis.The European respiratory journal · 2015Review
- Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanib.Drug design, development and therapy · 2015Review
- Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis.Core evidence · 2015Review
- Targeting the PDGF signaling pathway in the treatment of non-malignant diseases.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2014Article
- PDGF-D expression is down-regulated by TGFβ in fibroblasts.PloS one · 2014Article
- Profibrotic TGFβ responses require the cooperative action of PDGF and ErbB receptor tyrosine kinases.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Quinazoline derivatives: synthesis and bioactivities.Chemistry Central journal · 2013Article
- Reducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib.Drug design, development and therapy · 2013Review
- Increased expression of epidermal growth factor receptor (EGF-R) in patients with different forms of lung fibrosis.BioMed research international · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proliferation of myofibroblasts is a central feature of pulmonary fibrosis. In this study we have used tyrosine kinase inhibitors of the tyrphostin class to specifically block autophosphorylation of the platelet-derived growth factor receptor (PDGF-R) or epidermal growth factor receptor (EGF-R). AG1296 specifically inhibited autophosphorylation of PDGF-R and blocked PDGF-stimulated [3H]thymidine uptake by rat lung myofibroblasts in vitro. AG1478 was demonstrated as a selective blocker of EGF-R autophosphorylation and inhibited EGF-stimulated DNA synthesis in vitro. In a rat model of pulmonary fibrosis caused by intratracheal instillation of vanadium pentoxide (V2O5), intraperitoneal delivery of 50 mg/kg AG1296 or AG1478 in dimethylsulfoxide 1 hour before V2O5 instillation and again 2 days after instillation reduced the number of epithelial and mesenchymal cells incorporating bromodeoxyuridine (Brdu) by approximately 50% at 3 and 6 days after instillation. V2O5 instillation increased lung hydroxyproline fivefold 15 days after instillation, and AG1296 was more than 90% effective in preventing the increase in hydroxyproline, whereas AG1478 caused a 50% to 60% decrease in V2O5-stimulated hydroxyproline accumulation. These data provide evidence that PDGF and EGF receptor ligands are potent mitogens for collagen-producing mesenchymal cells during pulmonary fibrogenesis, and targeting tyrosine kinase receptors could offer a strategy for the treatment of fibrotic lung diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.