ArticleThe American journal of pathology1999
Use of tumor-specific gene expression for the differential diagnosis of neuroblastoma from other pediatric small round-cell malignancies.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 51 citations in OpenAlex.
- Overexpression of dopa decarboxylase in peritoneal dissemination of gastric cancer and its potential as a novel marker for the detection of peritoneal micrometastases with real-time RT-PCR.British journal of cancer · 2004Trial
- RNA modification regulator DDC in endometrial cancer affects the tumor microenvironment and patient prognosis.Scientific reports · 2023Article
- Gene Expression Analysis Reveals Prognostic Biomarkers of the Tyrosine Metabolism Reprogramming Pathway for Prostate Cancer.Journal of oncology · 2022Article
- Clinical application ofAmerican journal of nuclear medicine and molecular imaging · 2021Review
- Novel Gene and Network Associations Found for Acute Lymphoblastic Leukemia Using Case-Control and Family-Based Studies in Multiethnic Populations.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Flux balance analysis predicts Warburg-like effects of mouse hepatocyte deficient in miR-122a.PLoS computational biology · 2017Article
- Diagnostic FDG and FDOPA positron emission tomography scans distinguish the genomic type and treatment outcome of neuroblastoma.Oncotarget · 2016Article
- Role of genetic detection in peritoneal washes with gastric carcinoma: The past, present and future.World journal of gastrointestinal oncology · 2016Review
- L-Dopa decarboxylase (DDC) constitutes an emerging biomarker in predicting patients' survival with stomach adenocarcinomas.Journal of cancer research and clinical oncology · 2013Article
- L-DOPA decarboxylase mRNA expression is associated with tumor stage and size in head and neck squamous cell carcinoma: a retrospective cohort study.BMC cancer · 2012Article
- l-DOPA Decarboxylase (DDC) Expression Status as a Novel Molecular Tumor Marker for Diagnostic and Prognostic Purposes in Laryngeal Cancer.Translational oncology · 2012Article
- Release of membrane-associated L-dopa decarboxylase from human cells.Neurochemical research · 2011Article
- L-Dopa decarboxylase expression profile in human cancer cells.Molecular biology reports · 2011Article
- Quantitative expression analysis and prognostic significance of L-DOPA decarboxylase in colorectal adenocarcinoma.British journal of cancer · 2010Article
- Malignant small round cell tumors.Journal of cytology · 2009Article
- Differential gene expression profiles of gastric cancer cells established from primary tumour and malignant ascites.British journal of cancer · 2002Article
- Diagnosis and classification of small round-cell tumors of childhood.The American journal of pathology · 1999Article
- Diagnosis and classification of the small round-cell tumors of childhood.The American journal of pathology · 1999Review
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The differential diagnosis of neuroblastoma from other small round-cell tumors of childhood, although clinically of great importance, is sometimes difficult due to the almost indistinguishable appearance of such tumors by conventional microscopy. Because neuroblastomas are characterized by the synthesis of catecholamines, we investigated the possibility that expression of genes involved in this pathway could serve as a molecular marker for this disease. A reverse transcriptase polymerase chain reaction assay was used to analyze expression of tyrosine hydroxylase and dopa decarboxylase in 84 pediatric malignancies including 55 neuroblastomas, 6 Ewing's sarcomas/primitive neuroectodermal tumors, 7 lymphomas, 6 leukemias, 2 rhabdomyosarcomas, 6 osteosarcomas, and 2 phaeochromocytomas. Of the 55 neuroblastoma samples analyzed, 54 expressed clearly detectable levels of both genes. The one sample that did not express either of the genes was rediagnosed both clinically and by molecular genetic analysis as a Ewing's sarcoma. Of the 29 non-neuroblastoma tumor samples examined, the only tumor samples that expressed clearly detectable levels of both tyrosine hydroxylase and dopa decarboxylase were phaeochromocytomas. Like neuroblastomas, these tumors are characterized by high levels of catecholamines. These findings suggest that expression of genes involved in catecholamine biosynthesis may be useful for differentiating neuroblastoma from other small round-cell tumors of childhood.
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