ArticleOncogene1999
Cooperative activity between HER oncogenes and the tumor suppressor IRF-1 results in apoptosis.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
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- Identification of Neuregulin-2 as a novel stress granule component.BMB reports · 2016Article
- A murrel interferon regulatory factor-1: molecular characterization, gene expression and cell protection activity.Molecular biology reports · 2014Article
- Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons.PLoS pathogens · 2014Article
- Cooperative contributions of interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells.Journal of neuroinflammation · 2011Article
- The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer.International journal of breast cancer · 2011Article
- Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Article
- Influence of IFN-gamma and its receptors in human breast cancer.BMC cancer · 2007Article
- Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53.Molecular and cellular biology · 2004Article
- IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo.Oncogene · 2004Article
- IRF-1 reverts the transformed phenotype of oncogenically transformed cells in vitro and in vivo.Oncogene · 2003Article
- Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway.Oncogene · 2002Article
- Article
- A novel role for IRF-1 as a suppressor of apoptosis.Oncogene · 2000Article
- Interplay between DNA repair and inflammation, and the link to cancer.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tumor suppressor transcription factor IRF-1 inhibits cell growth. In this report we show that IRF-1 also induces apoptosis of highly transformed and tumorigenic cell lines. This activity of IRF-1 is demonstrated with cell lines expressing HER oncogenes and an activatable IRF-1 fusion protein. Growth of cell lines expressing inactive HER1 is inhibited on IRF-1 activation. In contrast, the same cells are killed by apoptosis when HER1 and IRF-1 are activated simultaneously. We identified promoters stimulated synergistically by IRF-1 and by activated HER1. To determine the signals causing transcriptional synergism and/or apoptosis we tried to modulate these effects by various dominant negative acting proteins. Dominant negative STAT5alpha abolished both induction of apoptosis and transcriptional synergy of IRF-1 and HER. Thus, these results provide new insights into the mechanism of oncogene-dependent apoptosis induced by the activation of a tumor suppressor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.