ArticleMolecular and cellular biochemistry1999
Increased peroxisomal fatty acid beta-oxidation and enhanced expression of peroxisome proliferator-activated receptor-alpha in diabetic rat liver.
Article in Molecular and cellular biochemistry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β.The Journal of biological chemistry · 2012Trial
- Peroxisomal regulation of energy homeostasis: Effect on obesity and related metabolic disorders.Molecular metabolism · 2022Review
- Changes in plasma fatty acids profile in hyperketonemic ewes during early lactation: a preliminary study.Scientific reports · 2022Article
- Exploring the Regulation of Jiangtang Tiaozhi Formula on the Biological Network of Obese T2DM Complicated With Dyslipidemia Based on Clinical Transcriptomics.Frontiers in endocrinology · 2022Article
- Dysregulation of ΔMolecular and cellular endocrinology · 2018Article
- Diabetic Cardiomyopathy: An Immunometabolic Perspective.Frontiers in endocrinology · 2017Review
- Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism.Scientific reports · 2016Article
- Identification of type 2 diabetes subgroups through topological analysis of patient similarity.Science translational medicine · 2015Article
- Peroxisomal biogenesis in ischemic brain.Antioxidants & redox signaling · 2015Article
- Taking diabetes to heart--deregulation of myocardial lipid metabolism in diabetic cardiomyopathy.Journal of the American Heart Association · 2013Review
- Peroxisomal acyl-CoA synthetases.Biochimica et biophysica acta · 2012Review
- Gemfibrozil, a lipid lowering drug, inhibits the activation of primary human microglia via peroxisome proliferator-activated receptor β.Neurochemical research · 2012Article
- Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling.Cancer research · 2011Article
- Daily exercise vs. caloric restriction for prevention of nonalcoholic fatty liver disease in the OLETF rat model.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Peroxisome proliferator-activated receptor {alpha} is responsible for the up-regulation of hepatic glucose-6-phosphatase gene expression in fasting and db/db Mice.The Journal of biological chemistry · 2011Article
- Peroxisomes and disease - an overview.International journal of biomedical science : IJBS · 2006Article
- Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.Environmental health perspectives · 2006Review
- Overexpression of c-myc in diabetic mice restores altered expression of the transcription factor genes that regulate liver metabolism.The Biochemical journal · 2002Article
- Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.The Journal of clinical investigation · 2002Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
To determine whether the increased fatty acid beta-oxidation in the peroxisomes of diabetic rat liver is mediated by a common peroxisome proliferation mechanism, we measured the activation of long-chain (LC) and very long chain (VLC) fatty acids catalyzed by palmitoyl CoA ligase (PAL) and lignoceryl CoA ligase and oxidation of LC (palmitic acid) and VLC (lignoceric acid) fatty acids by isotopic methods. Immunoblot analysis of acyl-CoA oxidase (ACO), and Northern blot analysis of peroxisome proliferator-activated receptor (PPAR-alpha), ACO, and PAL were also performed. The PAL activity increased in peroxisomes and mitochondria from the liver of diabetic rats by 2.6-fold and 2.1 -fold, respectively. The lignoceroyl-CoA ligase activity increased by 2.6-fold in diabetic peroxisomes. Palmitic acid oxidation increased in the diabetic peroxisomes and mitochondria by 2.5-fold and 2.7-fold, respectively, while lignoceric acid oxidation increased by 2.0-fold in the peroxisomes. Immunoreactive ACO protein increased by 2-fold in the diabetic group. The mRNA levels for PPAR-alpha, ACO and PAL increased 2.9-, 2.8- and 1.6-fold, respectively, in the diabetic group. These results suggest that the increased supply of fatty acids to liver in diabetic state stimulates the expression of PPAR-alpha and its target genes responsible for the metabolism of fatty acids.
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