Trial reportMolecular medicine (Cambridge, Mass.)1999
Predominance of Vgamma9/Vdelta2 T lymphocytes in the cerebrospinal fluid of children with tuberculous meningitis: reversal after chemotherapy.
Trial report in Molecular medicine (Cambridge, Mass.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- The changes and its significance of peripheral blood NK cells in patients with tuberculous meningitis.Frontiers in microbiology · 2024Article
- Recent advances in understanding the human host immune response in tuberculous meningitis.Frontiers in immunology · 2023Review
- Role of Vγ9vδ2 T lymphocytes in infectious diseases.Frontiers in immunology · 2022Review
- BTN3A Targeting Vγ9Vδ2 T Cells Antimicrobial Activity AgainstFrontiers in immunology · 2022Article
- Structure-Activity Relationships of Butyrophilin 3 Ligands.ChemMedChem · 2020Review
- Immune cell characteristics and cytokine responses in adult HIV-negative tuberculous meningitis: an observational cohort study.Scientific reports · 2019Observational
- Tuberculosis-associated IgA nephropathy.The Journal of international medical research · 2018Review
- Cerebrospinal fluid γδ T cell frequency is age-related: a case-control study of 435 children with inflammatory and non-inflammatory neurological disorders.Clinical and experimental immunology · 2018Article
- Next generation sequencing reveals changes of the γδ T cell receptor repertoires in patients with pulmonary tuberculosis.Scientific reports · 2018Article
- Morphine alters M. bovis infected microglia's ability to activate γδ T lymphocytes.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Article
- Regulation and function of IL-17A- and IL-22-producing γδ T cells.Cellular and molecular life sciences : CMLS · 2011Review
- γδ T-APCs: a novel tool for immunotherapy?Cellular and molecular life sciences : CMLS · 2011Review
- Persistent non-neoplastic gammadelta-T cells in cerebrospinal fluid of a patient with hepatosplenic (gammadelta) T cell lymphoma: a case report with 6 years of flow cytometry follow-up.International journal of clinical and experimental pathology · 2009Article
- Vdelta2+ gammadelta T cell function in Mycobacterium tuberculosis- and HIV-1-positive patients in the United States and Uganda: application of a whole-blood assay.The Journal of infectious diseases · 2005Article
- Vgamma2Vdelta2+ T cells and anti-microbial immune responses.Microbes and infection · 2003Review
- Adaptive immune response of Vgamma2Vdelta2 T cells: a new paradigm.Trends in immunology · 2003Review
- Inhibition of adaptive Vgamma2Vdelta2+ T-cell responses during active mycobacterial coinfection of simian immunodeficiency virus SIVmac-infected monkeys.Journal of virology · 2003Article
- Antigen recognition by human gamma delta T cells: pattern recognition by the adaptive immune system.Springer seminars in immunopathology · 2000Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe analyzed the gammadelta T cell composition and responses in the peripheral blood and cerebrospinal fluid (CSF) of children affected by tuberculous meningitis (TBM) and in control children. MATERIALS AND
methodsPeripheral blood and CSF samples were stimulated with different phosphoantigens and IL-2, and expansion of Vgamma9/Vdelta2 T cells assessed by FACS analysis. Vgamma9/Vdelta2 lines were obtained by culturing CSF or peripheral blood mononuclear cells (PBMC) in vitro with phosphoantigens and IL-2 for 2 months, and tested for proliferation and cytokine production in response to phosphoantigens. Vdelta2(D)Jdelta junctional sequence length was assessed by PCR.
resultsThe repertoire of gammadelta T cells from the CSF of TBM patients was characterized by the predominance of Vgamma9/Vdelta2 T lymphocytes, which accounted for >80% of gammadelta T cells. Vgamma9/Vdelta2 cells from the CSF of TBM children responded to different synthetic and natural (mycobacterial) phosphoantigens and produced discrete amounts of IFN-gamma and TNF-alpha. The in vitro expansion of Vgamma9/Vdelta2 T cells from CSF and peripheral blood of TBM patients prominently decreased following chemotherapy, and similarly, the proportion of ex vivo unstimulated Vgamma9/Vdelta2 T cells in CSF of TBM patients decreased to levels detected in the CSF of control subjects. Vdelta2 CDR3 TCR analysis showed that the remaining Vdelta2 cells in the CSF of TBM patients were still polyclonal.
conclusionsThese findings are consistent with an involvement of Vgamma9/Vdelta2 T cells in TBM. http://link. springer-ny.com/link/service/journals/00020/bibs/5n5p301. html
Indexed as
Identifiers
10390546PMC2230421W2107166858What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.