ArticleBritish journal of cancer1999
Effects of radiotherapy and estramustine on the microvasculature in malignant glioma.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- High-grade astrocytoma treated concomitantly with estramustine and radiotherapy.Journal of neuro-oncology · 2006Trial
- Mast cell degranulation and vascular endothelial growth factor expression in mouse skin following ionizing irradiation.Journal of radiation research · 2021Article
- Computed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer.World journal of gastroenterology · 2014Review
- Article
- Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma.Journal of neuro-oncology · 2010Article
- Effects of the VEGFR inhibitor ZD6474 in combination with radiotherapy and temozolomide in an orthotopic glioma model.Journal of neuro-oncology · 2008Article
- PET imaging with [18F]3'-deoxy-3'-fluorothymidine for prediction of response to neoadjuvant treatment in patients with rectal cancer.European journal of nuclear medicine and molecular imaging · 2007Article
- Protein expression in experimental malignant glioma varies over time and is altered by radiotherapy treatment.British journal of cancer · 2006Article
- The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model.British journal of cancer · 2004Article
- Rapid induction of long-lasting drug efflux activity in brain vascular endothelial cells but not malignant glioma following irradiation.Medical oncology (Northwood, London, England) · 2002Article
- Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Combination of endostatin and a protein kinase Calpha DNA enzyme improves the survival of rats with malignant glioma.Neoplasia (New York, N.Y.)Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumour angiogenesis is essential for progression of solid tumours and constitutes an interesting target for therapy. However, impaired tumour blood supply may also be an important obstacle for treatment by radiotherapy and chemotherapy. Estramustine has been shown to increase tumour blood flow and potentiate the effect of radiotherapy in experimental glioma. This study investigated the effects of fractionated radiotherapy and estramustine on angiogenesis in malignant glioma. The intracerebral BT4C rat glioma model was used and the animals were given whole brain radiotherapy 4 Gy x 5 days alone or in combination with estramustine 20 mg kg(-1) i.p. daily. Tumour microvascular density (MVD) was assessed by manual and computerized morphometrical analysis. Expression of vascular endothelial growth factor (VEGF) was studied by in situ hybridization. Radiotherapy decreased MVD to 157 vessels per mm2 compared to 217 vessels per mm2 in controls. Estramustine counteracted this anti-angiogenic effect and potentiated the anti-tumoural effect of radiotherapy. In addition, vessel size increased after estramustine treatment. Five days after completion of radiotherapy the expression of VEGF was increased in the centre of the tumours. In conclusion, fractionated radiotherapy decreases microvascular density in experimental malignant glioma. This effect was abolished by estramustine. The anti-vascular effect of irradiation is important to recognize when combining radiotherapy with cytotoxic drugs.
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