ArticleGenetics1999
Spatial and temporal distribution of the neutral polymorphisms in the last ZFX intron: analysis of the haplotype structure and genealogy.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
- Signatures of human European Palaeolithic expansion shown by resequencing of non-recombining X-chromosome segments.European journal of human genetics : EJHG · 2017Article
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- Genetic structure in African populations: implications for human demographic history.Cold Spring Harbor symposia on quantitative biology · 2009Review
- Tracing genetic history of modern humans using X-chromosome lineages.Human genetics · 2007Article
- Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin.Human genetics · 2005Article
- On the number of New World founders: a population genetic portrait of the peopling of the Americas.PLoS biology · 2005Article
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- Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity.American journal of human genetics · 2003Article
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- Evidence for balancing selection from nucleotide sequence analyses of human G6PD.American journal of human genetics · 2002Article
- Article
- Sequence variability of a human pseudogene.Genome research · 2001Article
- A highly variable segment of human subterminal 16p reveals a history of population growth for modern humans outstide Africa.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism.American journal of human genetics · 2000Article
- Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene.Genome research · 2000Article
- Archaic lineages in the history of modern humans.Genetics · 2000Article
- Contrasting evolutionary histories of two introns of the duchenne muscular dystrophy gene, Dmd, in humans.Genetics · 2000Article
- Recent common ancestry of human Y chromosomes: evidence from DNA sequence data.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
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Authors and funding
8 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With 10 segregating sites (simple nucleotide polymorphisms) in the last intron (1089 bp) of the ZFX gene we have observed 11 haplotypes in 336 chromosomes representing a worldwide array of 15 human populations. Two haplotypes representing 77% of all chromosomes were distributed almost evenly among four continents. Five of the remaining haplotypes were detected in Africa and 4 others were restricted to Eurasia and the Americas. Using the information about the ancestral state of the segregating positions (inferred from human-great ape comparisons), we applied coalescent analysis to estimate the age of the polymorphisms and the resulting haplotypes. The oldest haplotype, with the ancestral alleles at all the sites, was observed at low frequency only in two groups of African origin. Its estimated age of 740 to 1100 kyr corresponded to the time to the most recent common ancestor. The two most frequent worldwide distributed haplotypes were estimated at 550 to 840 and 260 to 400 kyr, respectively, while the age of the continentally restricted polymorphisms was 120 to 180 kyr and smaller. Comparison of spatial and temporal distribution of the ZFX haplotypes suggests that modern humans diverged from the common ancestral stock in the Middle Paleolithic era. Subsequent range expansion prevented substantial gene flow among continents, separating African groups from populations that colonized Eurasia and the New World.
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