SynthesisGenetics1999
Influence of sex, smoking and age on human hprt mutation frequencies and spectra.
Synthesis in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 48 citations in OpenAlex.
- Aging and the rise of somatic cancer-associated mutations in normal tissues.PLoS genetics · 2018Review
- Mutant TP53 disrupts age-related accumulation patterns of somatic mutations in multiple cancer types.Cancer genetics · 2016Article
- The cellular and molecular carcinogenic effects of radon exposure: a review.International journal of molecular sciences · 2013Review
- Somatic mutations in aging, cancer and neurodegeneration.Mechanisms of ageing and development · 2012Review
- Mutagenicity and potential carcinogenicity of thiopurine treatment in patients with inflammatory bowel disease.Cancer research · 2009Article
- A model system for analyzing somatic mutations in Drosophila melanogaster.Nature methods · 2007Article
- Qualitatively and quantitatively similar effects of active and passive maternal tobacco smoke exposure on in utero mutagenesis at the HPRT locus.BMC pediatrics · 2005Article
- Accumulation of somatic mutations in proliferating T cell clones from children treated for leukemia.Leukemia · 2001Article
- Human lung cancer and p53: the interplay between mutagenesis and selection.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice.Genetics · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Examination of the literature for hprt mutant frequencies from peripheral T cells yielded data from 1194 human subjects. Relationships between mutant frequency, age, sex, and smoking were examined, and the kinetics were described. Mutant frequency increases rapidly with age until about age 15. Afterward, the rate of increase falls such that after age 53, the hprt mutant frequency is largely stabilized. Sex had no effect on mutant frequency. Cigarette smoking increased mean mutant frequency compared to nonsmokers, but did not alter age vs. mutant frequency relationships. An hprt in vivo mutant database containing 795 human hprt mutants from 342 individuals was prepared. No difference in mutational spectra was observed comparing smokers to nonsmokers, confirming previous reports. Sex affected the frequency of deletions (>1 bp) that are recovered more than twice as frequently in females (P = 0. 008) compared to males. There is no indication of a significant shift in mutational spectra with age for individuals older than 19 yr, with the exception of A:T --> C:G transversions. These events are recovered more frequently in older individuals.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.