ArticleGenetics1999
Clustered microsatellite mutations in the pipefish Syngnathus typhle.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 72 citations in OpenAlex.
- Density drives polyandry and relatedness influences paternal success in the Pacific gooseneck barnacle, Pollicipes elegans.BMC evolutionary biology · 2014Article
- Genome-wide characterization of simple sequence repeats in cucumber (Cucumis sativus L.).BMC genomics · 2010Article
- Brooding fathers, not siblings, take up nutrients from embryos.Proceedings. Biological sciences · 2010Article
- Microsatellite evolution: Mutations, sequence variation, and homoplasy in the hypervariable avian microsatellite locus HrU10.BMC evolutionary biology · 2008Article
- Heterogeneity in the rate and pattern of germline mutation at individual microsatellite loci.Nucleic acids research · 2002Article
- Domain-level differences in microsatellite distribution and content result from different relative rates of insertion and deletion mutations.Genome research · 2002Article
- Mutation patterns at dinucleotide microsatellite loci in humans.American journal of human genetics · 2002Article
- Measurement of mutational flow implies both a high new-mutation rate for Huntington disease and substantial underascertainment of late-onset cases.American journal of human genetics · 2001Article
- Genetic parentage in large half-sib clutches: theoretical estimates and empirical appraisals.Genetics · 2000Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clustered mutations are copies of a mutant allele that enter a population's gene pool together due to replication from a premeiotic germline mutation and distribution to multiple successful gametes of an individual. Although the phenomenon has been studied in Drosophila and noted in a few other species, the topic has received scant attention despite claims of being of major importance to population genetics theory. Here we capitalize upon the reproductive biology of male-pregnant pipefishes to document the occurrence of clustered microsatellite mutations and to estimate their rates and patterns from family data. Among a total of 3195 embryos genetically screened from 110 families, 40% of the 35 detected de novo mutant alleles resided in documented mutational clusters. Most of the microsatellite mutations appeared to involve small-integer changes in repeat copy number, and they arose in approximately equal frequency in paternal and maternal germlines. These findings extend observations on clustered mutations to another organismal group and motivate a broader critique of the mutation cluster phenomenon. They also carry implications for the evolution of microsatellites with respect to mutational models and homoplasy among alleles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.