ArticleGenetics1999
Evidence for negative interference: clustering of crossovers close to the am locus in Neurospora crassa among am recombinants.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Statistical analysis and simulations that account for simultaneous effects of positive, negative, and no crossover interference in multilocus recombination data.BMC genomics · 2025Article
- Mapping functions.Genetica · 2008Article
- Rapid genetic mapping in Neurospora crassa.Fungal genetics and biology : FG & B · 2007Article
- Recombination hotspots flank the Cryptococcus mating-type locus: implications for the evolution of a fungal sex chromosome.PLoS genetics · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In response to a conflict between two mapping studies in the predicted orientation of the allele map with respect to the centromere, Fincham proposed that recombination events at the Neurospora am locus rarely have an associated crossover. Fincham considered that the elevated levels of crossing over between flanking markers in am recombinants resulted from negative interference, an increased probability of a nearby second event, and on this basis predicted a clustering of crossing over near am in these recombinants. In this article we reevaluate the data from three mapping studies of the am locus and report molecular evidence that shows crossovers to be clustered immediately proximal to am in am recombinants.
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