ArticleBiophysical journal1999
Atomic force microscopy of the submolecular architecture of hydrated ocular mucins.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- What role do mucins have in the development of laryngeal squamous cell carcinoma? A systematic review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2011Pooled it
- Comparative hydrodynamic and nanoscale imaging study on the interactions of teicoplanin-A2 and bovine submaxillary mucin as a model ocular mucin.Scientific reports · 2023Article
- Synthesis and biomedical applications of mucin mimic materials.Advanced drug delivery reviews · 2022Review
- Human ocular mucins: The endowed guardians of sight.Advanced drug delivery reviews · 2022Review
- Membrane-bound mucins of the airway mucosal surfaces are densely decorated with keratan sulfate: revisiting their role in the Lung's innate defense.Glycobiology · 2021Article
- Article
- The Interaction of the Gut Microbiota with the Mucus Barrier in Health and Disease in Human.Microorganisms · 2018Review
- Physical biology of the cancer cell glycocalyx.Nature physics · 2018Article
- Chemically tunable mucin chimeras assembled on living cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Enhanced self-association of mucins possessing the T and Tn carbohydrate cancer antigens at the single-molecule level.Biomacromolecules · 2012Article
- Distribution of sialic acids on mucins and gels: a defense mechanism.Biophysical journal · 2012Article
- Structure and biological roles of mucin-type O-glycans at the ocular surface.The ocular surface · 2010Review
- Formation of cholesterol crystals at a mucin coated substrate.Pharmaceutical research · 2006Article
- Dynamic molecular resolution imaging of preocular fluid impressions.The British journal of ophthalmology · 2004Article
- Human preocular mucins reflect changes in surface physiology.The British journal of ophthalmology · 2004Article
- Heterogeneity and persistence length in human ocular mucins.Biophysical journal · 2002Article
- Diffusion of macromolecules and virus-like particles in human cervical mucus.Biophysical journal · 2001Article
- From images to interactions: high-resolution phase imaging in tapping-mode atomic force microscopy.Biophysical journal · 2001Article
- Atomic force microscopy of gastric mucin and chitosan mucoadhesive systems.The Biochemical journal · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-resolution atomic force microscopy has been applied to the imaging of intact human ocular mucins in a near-physiological buffer. The mucins displayed a range of lengths from several hundred nanometers to several microns. By varying the ionic composition of the imaging environment, it was possible to image molecules rigidly fixed to the substrate and the motion of single molecules across the substrate. From static molecular images, high-resolution line profiles show a variation of up to +/-0.75 nm in thickness along the molecule. This variation is localized in regions of several tens of nanometers. It is interpreted in terms of the varying glycosylation along the mucin and is consistent with the known size of oligosaccharides in ocular mucins. The dynamic images indicate the possibility of following mucin interactions in situ.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.