ArticleBiophysical journal1999
Impact of mitochondrial Ca2+ cycling on pattern formation and stability.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- Robust assembly of electron transfer chain in the brain of naked mole-rats during aging.Organelle (Tucson, Ariz.) · 2025Article
- Mitochondrial chaperones in human health and disease.Free radical biology & medicine · 2022Review
- Challenges Associated with Interpreting Mechanisms of AF.Arrhythmia & electrophysiology review · 2020Review
- Changes in CaFrontiers in physiology · 2019Article
- Spatial separation of two different pathways accounting for the generation of calcium signals in astrocytes.PLoS computational biology · 2017Article
- Characterization of the effect of the mitochondrial protein Hint2 on intracellular Ca(2+) dynamics.Biophysical journal · 2013Article
- Timescales of IP(3)-evoked Ca(2+) spikes emerge from Ca(2+) puffs only at the cellular level.Biophysical journal · 2011Article
- The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention.Current pharmaceutical design · 2011Article
- Ca2+ spiral waves in a spatially discrete and random medium.European biophysics journal : EBJ · 2009Article
- Mitochondria, calcium and cell death: a deadly triad in neurodegeneration.Biochimica et biophysica acta · 2009Review
- Mitochondria and Ca(2+) signaling: old guests, new functions.Pflugers Archiv : European journal of physiology · 2007Review
- Ca2+ shuttling between endoplasmic reticulum and mitochondria underlying Ca2+ oscillations.EMBO reports · 2006Article
- A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Release currents of IP(3) receptor channel clusters and concentration profiles.Biophysical journal · 2004Article
- Modeling the dependence of the period of intracellular Ca2+ waves on SERCA expression.Biophysical journal · 2003Article
- On the role of stochastic channel behavior in intracellular Ca2+ dynamics.Biophysical journal · 2003Article
- Calcium waves in agarose gel with cell organelles: implications of the velocity curvature relationship.Biophysical journal · 2001Article
- Mitochondrial control of calcium-channel gating: a mechanism for sustained signaling and transcriptional activation in T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Energization of mitochondria significantly alters the pattern of Ca2+ wave activity mediated by activation of the inositol (1,4,5) trisphosphate (IP3) receptor (IP3R) in Xenopus oocytes. The number of pulsatile foci is reduced and spiral Ca2+ waves are no longer observed. Rather, target patterns of Ca2+ release predominate, and when fragmented, fail to form spirals. Ca2+ wave velocity, amplitude, decay time, and periodicity are also increased. We have simulated these experimental findings by supplementing an existing mathematical model with a differential equation for mitochondrial Ca2+ uptake and release. Our calculations show that mitochondrial Ca2+ efflux plays a critical role in pattern formation by prolonging the recovery time of IP3Rs from a refractory state. We also show that under conditions of high energization of mitochondria, the Ca2+ dynamics can become bistable with a second stable stationary state of high resting Ca2+ concentration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.