ArticleProtein science : a publication of the Protein Society1999
Simple sequence is abundant in eukaryotic proteins.
Article in Protein science : a publication of the Protein Society, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A benchmarking framework for comparative evaluation of low-complexity region detection tools in the human proteome.Scientific reports · 2026Article
- Kingdom-wide CRISPR guide design with ALLEGRO.Nucleic acids research · 2025Article
- Terminal regions of a protein are a hotspot for low complexity regions and selection.Open biology · 2024Article
- Evolution of Transcript Abundance is Influenced by Indels in Protein Low Complexity Regions.Journal of molecular evolution · 2024Article
- Benchmarking of force fields to characterize the intrinsically disordered R2-FUS-LC region.Scientific reports · 2023Article
- Classification of proteins inducing liquid-liquid phase separation: sequential, structural and functional characterization.Journal of biochemistry · 2023Article
- The Josephin domain (JD) containing proteins are predicted to bind to the same interactors: Implications for spinocerebellar ataxia type 3 (SCA3) studies usingFrontiers in molecular neuroscience · 2023Article
- The sequence context in poly-alanine regions: structure, function and conservation.Bioinformatics (Oxford, England) · 2022Article
- Phase separation of low-complexity domains in cellular function and disease.Experimental & molecular medicine · 2022Review
- Low Complexity Regions in Mammalian Proteins are Associated with Low Protein Abundance and High Transcript Abundance.Molecular biology and evolution · 2022Article
- Amino acid homorepeats in proteins.Nature reviews. Chemistry · 2020Review
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- Tandem amino acid repeats in the green anole (Anolis carolinensis) and other squamates may have a role in increasing genetic variability.BMC genomics · 2016Article
- The Octatricopeptide Repeat Protein Raa8 Is Required for Chloroplast trans Splicing.Eukaryotic cell · 2015Article
- Increased substitution rates surrounding low-complexity regions within primate proteins.Genome biology and evolution · 2014Article
- Discovering putative prion sequences in complete proteomes using probabilistic representations of Q/N-rich domains.BMC genomics · 2013Article
- Dissecting the role of low-complexity regions in the evolution of vertebrate proteins.BMC evolutionary biology · 2012Article
- Genome-wide comparative analysis of simple sequence coding repeats among 25 insect species.Gene · 2012Article
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Abstract
All proteins of Saccharomyces cerevisiae have been compared to determine how frequently segments from one protein are present in other proteins. Proteins that are recently evolutionarily related were excluded. The most frequently present protein segments are long, tandem repetitions of a single amino acid. For some of these segments, up to 14% of all proteins in the genome were found to have similar peptides within them. These peptide segments may not be functional protein domains. Although they are the most common shared feature of yeast proteins, their ubiquity and simplicity argue that their probable function may be to simply serve as spacers between other protein motifs.
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