ArticleJournal of anatomy1999
Immunohistochemical evidence suggests intrinsic regulatory activity of human eccrine sweat glands.
Article in Journal of anatomy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Neuronal nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo.The Journal of physiology · 2008Trial
- Peripheral amplification of sweating--a role for calcitonin gene-related peptide.The Journal of physiology · 2006Trial
- Characterization of microvessels in the human forehead dermis using intravascular dual perfusion and immunofluorescence staining.Scientific reports · 2025Article
- iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Eccrine sweat gland development and sweat secretion.Experimental dermatology · 2015Review
- Abolished InsP3R2 function inhibits sweat secretion in both humans and mice.The Journal of clinical investigation · 2014Article
- De novo epidermal regeneration using human eccrine sweat gland cells: higher competence of secretory over absorptive cells.The Journal of investigative dermatology · 2014Article
- Differential expression of dipeptidyl peptidase IV in human versus cynomolgus monkey skin eccrine sweat glands.Journal of molecular histology · 2013Article
- Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Acupuncture as treatment of hot flashes and the possible role of calcitonin gene-related Peptide.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Nonselective NOS inhibition blunts the sweat response to exercise in a warm environment.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- S-100 protein immunoreactivity in the upper eyelid of the sheep Ovis aries.Journal of molecular histology · 2004Article
- Ultrastructure of submucosal glands in human anterior middle nasal turbinates.Journal of anatomy · 2000Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunohistochemistry of normal eccrine sweat glands was performed on paraffin sections of human skin. Immunoreactivity (ir) for neuron specific enolase, S100 protein (S100), regulatory peptides, nitric oxide synthase type I (NOS-I) and choline-acetyltransferase (ChAT) was found in small nerve bundles close to sweat glands. In the glands, secretory cells were labelled with anticytokeratin antibody. Using antibodies to S100, calcitonin gene-related peptide (CGRP) and substance P (SP) a specific distribution pattern was found in secretory cells. Granulated (dark) and parietal (clear) cells were immunopositive for CGRP, and S100 and SP, respectively. Immunoreactivity was diffuse in the cytoplasm for CGRP and S100, and peripheral for SP. Myoepithelial cells were not labelled. Electron microscopy revealed electron dense granules, probably containing peptide, in granulated cells. Using antibodies to NOS-I and ChAT, ir was exclusively found in myoepithelial cells. Immunoreactivity for the atrial natriuretic peptide was absent in sweat glands. These results provide evidence for the presence of both regulatory peptides involved in vasodilation and key enzymes for the synthesis of nitric oxide and acetylcholine in the secretory coil of human sweat glands. It is suggested that human sweat glands are capable of some intrinsic regulation in addition to that carried out by their nerve supply.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.