ArticleGenes & development1999
Developmental regulation of SR protein phosphorylation and activity.
Article in Genes & development, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Functional Characteristics and Regulated Expression of Alternatively Spliced Tissue Factor: An Update.Cancers · 2021Review
- Vaccinia Virus as a Master of Host Shutoff Induction: Targeting Processes of the Central Dogma and Beyond.Pathogens (Basel, Switzerland) · 2020Review
- Emerging roles of histone modifications and HDACs in RNA splicing.Nucleic acids research · 2019Review
- Exploring intrinsically disordered proteins in Chlamydomonas reinhardtii.Scientific reports · 2018Article
- Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation.Molecular cell · 2018Article
- Increased Serine-Arginine (SR) Protein Phosphorylation Changes Pre-mRNA Splicing in Hypoxia.The Journal of biological chemistry · 2015Article
- Multifunctional RNA processing protein SRm160 induces apoptosis and regulates eye and genital development in Drosophila.Genetics · 2014Article
- Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence.Oncogene · 2013Article
- Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones.Genes & development · 2009Article
- Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing.PloS one · 2007Article
- Dsk1p kinase phosphorylates SR proteins and regulates their cellular localization in fission yeast.The Biochemical journal · 2007Article
- Serine/arginine-rich splicing factors belong to a class of intrinsically disordered proteins.Nucleic acids research · 2006Article
- Reversible phosphorylation differentially affects nuclear and cytoplasmic functions of splicing factor 2/alternative splicing factor.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation.The EMBO journal · 2003Article
- Interactions between two fission yeast serine/arginine-rich proteins and their modulation by phosphorylation.The Biochemical journal · 2002Article
- Multiple roles for SR proteins in trans splicing.Molecular and cellular biology · 2002Article
- Regulation of SR protein localization during development.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions.Molecular biology of the cell · 2001Article
- 3' splice site recognition in nematode trans-splicing involves enhancer-dependent recruitment of U2 snRNP.RNA (New York, N.Y.) · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Serine/arginine-rich splicing factors (SR proteins) are substrates for serine phosphorylation that can regulate SR protein function. We have observed gross changes in SR protein phosphorylation during early development coincident with major zygotic gene activation in the nematode Ascaris lumbricoides. These differences correlate with large-scale changes in SR protein activity in promoting both trans- and cis-splicing. Importantly, inactive early stage extracts can be made splicing competent on addition of later stage SR proteins. These data suggest that changes in SR protein phosphorylation have a role in the activation of pre-mRNA splicing during early development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.