ArticleThe Journal of cell biology1999
Assembly of 5S ribosomal RNA is required at a specific step of the pre-rRNA processing pathway.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Article
- The Hsp70 homolog Ssb affects ribosome biogenesis via the TORC1-Sch9 signaling pathway.Nature communications · 2017Article
- Placeholder factors in ribosome biogenesis: please, pave my way.Microbial cell (Graz, Austria) · 2017Review
- Sub1 and Maf1, two effectors of RNA polymerase III, are involved in the yeast quiescence cycle.PloS one · 2014Article
- 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.Cell reports · 2013Article
- RNA content in the nucleolus alters p53 acetylation via MYBBP1A.The EMBO journal · 2011Article
- The essential nucleolar yeast protein Nop8p controls the exosome function during 60S ribosomal subunit maturation.PloS one · 2011Article
- Distinct ribosome maturation defects in yeast models of Diamond-Blackfan anemia and Shwachman-Diamond syndrome.Haematologica · 2010Article
- Assembly of the Trypanosoma brucei 60S ribosomal subunit nuclear export complex requires trypanosome-specific proteins P34 and P37.Eukaryotic cell · 2009Article
- Different mechanisms for pseudouridine formation in yeast 5S and 5.8S rRNAs.Molecular and cellular biology · 2008Article
- Trypanosoma brucei RNA binding proteins p34 and p37 mediate NOPP44/46 cellular localization via the exportin 1 nuclear export pathway.Eukaryotic cell · 2007Article
- Assembly factors Rpf2 and Rrs1 recruit 5S rRNA and ribosomal proteins rpL5 and rpL11 into nascent ribosomes.Genes & development · 2007Article
- Two trypanosome-specific proteins are essential factors for 5S rRNA abundance and ribosomal assembly in Trypanosoma brucei.Eukaryotic cell · 2007Article
- A bona fide La protein is required for embryogenesis in Arabidopsis thaliana.Nucleic acids research · 2007Article
- Synergistic defect in 60S ribosomal subunit assembly caused by a mutation of Rrs1p, a ribosomal protein L11-binding protein, and 3'-extension of 5S rRNA in Saccharomyces cerevisiae.Nucleic acids research · 2005Article
- NVL2 is a nucleolar AAA-ATPase that interacts with ribosomal protein L5 through its nucleolar localization sequence.Molecular biology of the cell · 2004Article
- Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation.RNA (New York, N.Y.) · 2004Article
- Genome-wide location of yeast RNA polymerase III transcription machinery.The EMBO journal · 2003Article
- Identification and characterization of transcription factor IIIA and ribosomal protein L5 from Arabidopsis thaliana.Nucleic acids research · 2003Article
- Conventional and nonconventional roles of the nucleolus.International review of cytology · 2002Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A collection of yeast strains surviving with mutant 5S RNA has been constructed. The mutant strains presented alterations of the nucleolar structure, with less granular component, and a delocalization of the 25S rRNA throughout the nucleoplasm. The 5S RNA mutations affected helix I and resulted in decreased amounts of stable 5S RNA and of the ribosomal 60S subunits. The shortage of 60S subunits was due to a specific defect in the processing of the 27SB precursor RNA that gives rise to the mature 25S and 5.8S rRNA. The processing rate of the 27SB pre-rRNA was specifically delayed, whereas the 27SA and 20S pre-rRNA were processed at a normal rate. The defect was partially corrected by increasing the amount of mutant 5S RNA. We propose that the 5S RNA is recruited by the pre-60S particle and that its recruitment is necessary for the efficient processing of the 27SB RNA precursor. Such a mechanism could ensure that all newly formed mature 60S subunits contain stoichiometric amounts of the three rRNA components.
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