Evidence map›Paper›PMID 10383553›Full record

ArticleBritish journal of clinical pharmacology1999

Target concentration intervention: beyond Y2K.

N H Holford

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of clinical pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. TDM is dead. Long live TCI!British journal of clinical pharmacology · 2022
    Review
  9. On precision dosing of oral small molecule drugs in oncology.British journal of clinical pharmacology · 2021
    Review
  10. Article
  11. Review
  12. Article
  13. Pharmacodynamic principles and target concentration intervention.Translational and clinical pharmacology · 2018
    Review
  14. The clinical utility of pharmacometric models.British journal of clinical pharmacology · 2018
    Article
  15. Inter occasion variability in individual optimal design.Journal of pharmacokinetics and pharmacodynamics · 2015
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

N H HolfordDepartment of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Target concentration intervention (TCI) is proposed as an alternative conceptual strategy to therapeutic drug monitoring (TDM). It is argued that the idea of a therapeutic range has limited the interpretation of measured drug concentrations and diminished the anticipated clinical benefit to patients by use of an oversimplified pharmacodynamic model. TCI on the other hand embraces pharmacokinetic and pharmacodynamic concepts and uses the idea of a target effect and associated target concentration to make rational individual dose decisions.

Indexed as

Dose-Response Relationship, DrugDrug MonitoringData Interpretation, StatisticalHumansPharmacokineticsPharmacology, Clinical

Identifiers

PMID10383553
PMCPMC2014870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.