ArticleThe British journal of ophthalmology1999
Comparison of the levels of hepatocyte growth factor and vascular endothelial growth factor in aqueous fluid and serum with grades of retinopathy in patients with diabetes mellitus.
Article in The British journal of ophthalmology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Serum Vascular Endothelial Growth Factor Levels Correlate with Severity of Retinopathy in Diabetic Patients: A Systematic Review and Meta-Analysis.Disease markers · 2019 · on this mapPooled it
- Effect of pan retinal photocoagulation on the serum levels of vascular endothelial growth factor in diabetic patients.International ophthalmology · 2011Trial
- Biochemical Changes in Anterior Chamber of the Eye in Diabetic Patients-A Review.Journal of clinical medicine · 2024Review
- Comparison of the efficacy of intravitreal Anti-VEGF versus intravitreal dexamethasone implant in treatment resistant diabetic Macular Edema.BMC ophthalmology · 2023Article
- Changes in aqueous and vitreous inflammatory cytokine levels in proliferative diabetic retinopathy: a systematic review and meta-analysis.Eye (London, England) · 2022Review
- Comparison of VEGF level in tears post phacoemulsification between non-proliferative diabetic retinopathy and non-diabetic patients.Journal of diabetes and metabolic disorders · 2021Article
- Inflammatory and angiogenic biomarkers in diabetic retinopathy.Biochemia medica · 2020Review
- Endothelial Dysfunction in Diabetic Retinopathy.Frontiers in endocrinology · 2020Review
- Aptamer-based search for correlates of plasma and serum water TBiomarker research · 2018Article
- Time-dependent expression of PEDF and VEGF in blood serum and retina of rats with oxygen-induced retinopathy.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2015Article
- Diabetic Retinopathy: Vascular and Inflammatory Disease.Journal of diabetes research · 2015Review
- Modulation of CD44 Activity by A6-Peptide.Frontiers in immunology · 2015Review
- Induction of VEGFA mRNA translation by CoCl2 mediated by HuR.RNA biology · 2015Article
- Effect of pan-retinal laser photocoagulation on plasma VEGF, endothelin-1 and nitric oxide in PDR.International journal of ophthalmology · 2010Article
- The pathologic continuum of diabetic vascular disease.Journal of the American College of Cardiology · 2009Review
- Nerve growth factor (NGF) and lenses: effects of NGF in an in vitro rat model of cataract.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2003Article
- The absence of diabetic retinopathy in patients with retinitis pigmentosa: implications for pathophysiology and possible treatment.The British journal of ophthalmology · 2001Review
- Hepatocyte growth factor in vitreous and serum from patients with proliferative diabetic retinopathy.The British journal of ophthalmology · 2000Article
- Increased levels of vascular endothelial growth factor in the aqueous humor of patients with diabetic retinopathy.Indian journal of ophthalmologyArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the relation between the stages of diabetic retinopathy (DR) and the levels of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) in aqueous fluid and serum.
methodsLevels of HGF and VEGF in serum and aqueous humour obtained during ocular surgery were measured by enzyme linked immunosorbent assay in 58 diabetic patients with 32 non-diabetic patients (NDM) as controls. The patients with diabetes were classified into three groups according to the stage of DR: no DR (NDR; 15 cases), non-proliferative DR (NPDR; six cases), and proliferative DR (PDR; 37 cases).
resultsNo significant differences were found between any of the groups in serum concentrations of HGF or VEGF. The aqueous HGF levels increased with the stage of DR: NDM, median 397 pg/ml, range 133-930 pg/ml; NDR, 371 pg/ml, 142-1536 pg/ml; NPDR, 455 pg/ml, 162-1007 pg/ml; and PDR, 638 pg/ml, 187-2222 pg/ml. The aqueous VEGF levels in PDR (median 212 pg/ml, range 14-1216 pg/ml) were significantly higher than in NDM (105 pg/ml, 9-203 pg/ml), but aqueous HGF concentrations were unrelated to those of VEGF.
conclusionThe results of the present study suggest that both HGF and VEGF present in the ocular tissues may play important roles in the progression of DR.
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