ArticleThe Journal of physiology1999
Serotonergic modulation of hyperpolarization-activated current in acutely isolated rat dorsal root ganglion neurons.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 118 citations in OpenAlex.
- GLP-1 enhances hyperpolarization-activated currents of mouse cerebellar Purkinje cellFrontiers in molecular neuroscience · 2023Article
- Serotonergic 5-HTCurrent neuropharmacology · 2023Review
- 5-HTFrontiers in molecular neuroscience · 2022Article
- Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids.Frontiers in molecular neuroscience · 2022Article
- Involvement of Serotonergic System in Oxaliplatin-Induced Neuropathic Pain.Biomedicines · 2021Review
- Serotonergic Modulation of Nociceptive Circuits in Spinal Cord Dorsal Horn.Current neuropharmacology · 2019Review
- Serotonin controls initiation of locomotion and afferent modulation of coordination via 5-HTThe Journal of physiology · 2017Article
- Human Tear Serotonin Levels Correlate with Symptoms and Signs of Dry Eye.Ophthalmology · 2015Article
- Serotonergic regulation of excitability of principal cells of the dorsal cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- HCN channels--modulators of cardiac and neuronal excitability.International journal of molecular sciences · 2015Review
- Inhibition of Hyperpolarization-Activated Cation Current in Medium-Sized DRG Neurons Contributed to the Antiallodynic Effect of Methylcobalamin in the Rat of a Chronic Compression of the DRG.Neural plasticity · 2015Article
- Epigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part I).Medical science monitor : international medical journal of experimental and clinical research · 2014Review
- 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders.Frontiers in cellular neuroscience · 2014Review
- Light-activated serotonin for exploring its action in biological systems.Chemistry & biology · 2013Article
- A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons.Nature neuroscience · 2013Article
- Expression and properties of hyperpolarization-activated current in rat dorsal root ganglion neurons with known sensory function.The Journal of physiology · 2012Article
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- Enhanced excitability of small dorsal root ganglion neurons in rats with bone cancer pain.Molecular pain · 2012Article
- Up-regulation of tetrodotoxin-sensitive sodium currents by prostaglandin E₂ in type-4 rat dorsal root ganglion cells.Neuroscience · 2011Article
- A transcriptomic analysis of type I-III neurons in the bed nucleus of the stria terminalis.Molecular and cellular neurosciences · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
1. The effect of serotonin (5-HT) on the hyperpolarization-activated cation current (IH) was studied in small-, medium- and large-diameter acutely isolated rat dorsal root ganglion (DRG) cells, including cells categorized as type 1, 2, 3 and 4 based on membrane properties. 5-HT increased IH in 91 % of medium-diameter DRG cells (including type 4) and in 67 % of large-diameter DRG cells, but not other DRG cell types. 2. The increase of IH by 5-HT was antagonized by spiperone but not cyanopindolol, and was mimicked by 5-carboxyamidotryptamine, but not (+)-8-hydroxydipropylaminotetralin (8-OH-DPAT) or cyanopindolol. These data suggested the involvement of 5-HT7 receptors, which were shown to be expressed by medium-diameter DRG cells using RT-PCR analysis. 3. 5-HT shifted the conductance-voltage relationship of IH by +6 mV without changing peak conductance. The effects of 5-HT on IH were mimicked and occluded by forskolin, but not by inactive 1,9-dideoxy forskolin. 4. At holding potentials negative to -50 mV, 5-HT increased steady-state inward current and instantaneous membrane conductance (fast current). The 5-HT-induced inward current and fast current were blocked by Cs+ but not Ba2+ and reversed at -23 mV, consistent with the properties of tonically activated IH. 5. In medium-diameter neurons recorded from in the current clamp mode, 5-HT depolarized the resting membrane potential, decreased input resistance and facilitated action potential generation by anode-break excitation. 6. The above data suggest that in distinct subpopulations of DRG neurons, 5-HT increases cAMP levels via activation of 5-HT7 receptors, which shifts the voltage dependence of IH to more depolarized potentials and increases neuronal excitability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.