ArticlePlant molecular biology1999
Characterization of ATDRG1, a member of a new class of GTP-binding proteins in plants.
Article in Plant molecular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Developmentally regulated GTPases: structure, function and roles in disease.Cellular and molecular life sciences : CMLS · 2021Review
- DRG1 is a potential oncogene in lung adenocarcinoma and promotes tumor progression via spindle checkpoint signaling regulation.Oncotarget · 2016Article
- Nucleotide polymorphism affecting FLC expression underpins heading date variation in horticultural brassicas.The Plant journal : for cell and molecular biology · 2016Article
- Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance.eLife · 2015Article
- Transcriptome analysis of Arabidopsis GCR1 mutant reveals its roles in stress, hormones, secondary metabolism and phosphate starvation.PloS one · 2015Article
- Development-associated microRNAs in grains of wheat (Triticum aestivum L.).BMC plant biology · 2013Article
- Article
- Protocol: A simple phenol-based method for 96-well extraction of high quality RNA from Arabidopsis.Plant methods · 2011Article
- FRIGIDA delays flowering in Arabidopsis via a cotranscriptional mechanism involving direct interaction with the nuclear cap-binding complex.Plant physiology · 2009Article
- Type B response regulators of Arabidopsis play key roles in cytokinin signaling and plant development.The Plant cell · 2008Article
- Expression analysis and subcellular localization of the Arabidopsis thaliana G-protein beta-subunit AGB1.Plant cell reports · 2007Article
- Small RNA-mediated chromatin silencing directed to the 3' region of the Arabidopsis gene encoding the developmental regulator, FLC.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Variation in the epigenetic silencing of FLC contributes to natural variation in Arabidopsis vernalization response.Genes & development · 2006Article
- Cosuppression of eukaryotic release factor 1-1 in Arabidopsis affects cell elongation and radial cell division.Plant physiology · 2005Article
- Heterotrimeric and unconventional GTP binding proteins in plant cell signaling.The Plant cell · 2002Review
- Completing the heterotrimer: isolation and characterization of an Arabidopsis thaliana G protein gamma-subunit cDNA.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the initial characterization of an Arabidopsis thaliana cDNA (atdrg1), a member of a new class of GTP-binding proteins (G-proteins) in plants. The predicted ATDRG1 protein contains all five structural motifs characteristic of the G-protein superfamily. Apart from these motifs, the amino acid sequence differs substantially from all known G-proteins except for a recently discovered new family named developmentally regulated G-proteins (DRGs). Sequences closely related to atdrg1 are found in species as distant as human (80% amino acid conservation), Drosophila (74%), yeast (77%) and Caenorhabditis elegans (77%). The remarkable evolutionary conservation of these proteins suggests an important, but as yet unclear role. Phylogenetic analysis of the available homologous sequences strongly suggests a diphyletic origin of the eukaryotic DRG proteins. Northern analysis shows high levels of atdrg1 mRNA in all Arabidopsis tissues studied, and homologues of atdrg1 are present throughout the plant kingdom. In situ hybridization reveals that atdrg1 is highly expressed in actively growing tissues and reproductive organs. Southern analysis indicates the presence of either one or two copies of atdrg1 in the Arabidopsis genome. Immunolocalization studies show that the protein is present in cytoplasmic vesicles found mainly in actively growing tissues suggesting a putative role for ATDRG1 in either the regulation of vesicle transport or the regulation of enzymes involved in storage protein processing.
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