ReviewOncogene1999
Myc-mediated transformation: the repression connection.
Review in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 125 citations in OpenAlex.
- Review
- Transactivation Domain of Human c-Myc Is Essential to Alleviate Poly(Q)-Mediated Neurotoxicity in Drosophila Disease Models.Journal of molecular neuroscience : MN · 2017Article
- Mxi1 and mxi1-0 antagonize N-myc function and independently mediate apoptosis in neuroblastoma.Translational oncology · 2015Article
- Identification of molecular sub-networks associated with cell survival in a chronically SIVmac-infected human CD4+ T cell line.Virology journal · 2014Article
- MYC cofactors: molecular switches controlling diverse biological outcomes.Cold Spring Harbor perspectives in medicine · 2014Review
- Reversal by RARα agonist Am580 of c-Myc-induced imbalance in RARα/RARγ expression during MMTV-Myc tumorigenesis.Breast cancer research : BCR · 2012Article
- Therapeutic potential of c-Myc inhibition in the treatment of hypertrophic cardiomyopathy.Therapeutic advances in chronic disease · 2011Article
- Myc-induced microRNAs integrate Myc-mediated cell proliferation and cell fate.Cancer research · 2010Article
- Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor.Molecular and cellular biology · 2010Article
- Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades.Current cancer drug targets · 2009Review
- Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1.The Journal of biological chemistry · 2008Article
- Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: identification of the c-myc regulatory gene network.BMC systems biology · 2008Article
- Indirect genomic effects on survival from gene expression data.Genome biology · 2008Article
- Nuclear receptor hepatocyte nuclear factor 4alpha1 competes with oncoprotein c-Myc for control of the p21/WAF1 promoter.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Statistical analysis of the genomic distribution and correlation of regulatory elements in the ENCODE regions.Genome research · 2007Article
- YB-1 is a Transcription/Translation Factor that Orchestrates the Oncogenome by Hardwiring Signal Transduction to Gene Expression.Translational oncogenomics · 2007Article
- Global mapping of c-Myc binding sites and target gene networks in human B cells.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
- Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster.Molecular and cellular biology · 2005Article
- Stimulation of Myc transactivation by the TATA binding protein in promoter-reporter assays.BMC biochemistry · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myc is an important regulator of many cellular processes, including growth promotion, differentiation, and apoptosis. The mechanisms underlying Myc biological activity, however, remain elusive. For many years, research in the field has focused on the idea of Myc as a transactivator of gene expression. More recently, alternative mechanisms of Myc function have been proposed, including gene repression. In this review we present several lines of evidence to support a connection between Myc-mediated transformation and transcriptional repression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.