ArticleProceedings of the National Academy of Sciences of the United States of America1999
Cdc20 associates with the kinase aurora2/Aik.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- The Unexpected Roles of Aurora A Kinase in Gliobastoma Recurrences.Targeted oncology · 2017Review
- Quercetin suppresses lung cancer growth by targeting Aurora B kinase.Cancer medicine · 2016Article
- Dispensability of the SAC Depends on the Time Window Required by Aurora B to Ensure Chromosome Biorientation.PloS one · 2015Article
- p31(comet) inactivates the chemically induced Mad2-dependent spindle assembly checkpoint and leads to resistance to anti-mitotic drugs.SpringerPlus · 2013Article
- Aurora kinase inhibitors--rising stars in cancer therapeutics?Molecular cancer therapeutics · 2010Review
- Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.Chromosoma · 2008Article
- Discovery of Time-Delayed Gene Regulatory Networks based on temporal gene expression profiling.BMC bioinformatics · 2006Article
- Aurora kinases: shining lights on the therapeutic horizon?Oncogene · 2005Review
- Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property.Molecular and cellular biology · 2005Article
- Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2004Review
- AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer.Oncogene · 2003Article
- Biphasic activation of Aurora-A kinase during the meiosis I- meiosis II transition in Xenopus oocytes.Molecular and cellular biology · 2003Article
- The centrosomal kinase Aurora-A/STK15 interacts with a putative tumor suppressor NM23-H1.Nucleic acids research · 2002Article
- Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit.Genes & development · 2002Article
- The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with the inner centromere protein Pic1 and mediates chromosome segregation and cytokinesis.Molecular biology of the cell · 2002Article
- Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases.Molecular and cellular biology · 2002Article
- The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint.Genes & development · 2001Article
- Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation.The Journal of cell biology · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cdc20/fizzy family proteins are involved in activation of the anaphase-promoting complex/cyclosome, which catalyzes the ubiquitin-dependent proteolysis of cell cycle regulatory proteins such as anaphase inhibitors and mitotic cyclins, leading to chromosome segregation and exit from mitosis. Previous work has shown that human Cdc20 (hCdc20/p55CDC) associates with one or more kinases. We report here that Cdc20-associated myelin basic protein kinase activity peaks sharply in early M phase (embryonic cells) or in G2 phase (somatic cells). In HeLa cells, Cdc20 is associated with the kinase aurora2/Aik. Aurora2/Aik is a member of the aurora/Ipl1 family of kinases that, like Cdc20, previously has been shown to be localized at mitotic spindle poles and is involved in regulating chromosome segregation and maintaining genomic stability. The demonstration that Cdc20 is associated with aurora2/Aik suggests that some function of Cdc20 is carried out or regulated through its association with aurora2/Aik.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.