ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Differential distribution of intracellular glutamate receptors in dendrites.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
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- Review of Post-embedding Immunogold Methods for the Study of Neuronal Structures.Frontiers in neuroanatomy · 2021Review
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
- Conductive Hearing Loss Has Long-Lasting Structural and Molecular Effects on Presynaptic and Postsynaptic Structures of Auditory Nerve Synapses in the Cochlear Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Zebrafish Get Connected: Investigating Neurotransmission Targets and Alterations in Chemical Toxicity.Toxics · 2016Article
- Acoustic trauma slows AMPA receptor-mediated EPSCs in the auditory brainstem, reducing GluA4 subunit expression as a mechanism to rescue binaural function.The Journal of physiology · 2016Article
- N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo.Hippocampus · 2014Article
- Mapping and morphometric analysis of synapses and spines on fusiform cells in the dorsal cochlear nucleus.Frontiers in systems neuroscience · 2014Article
- Mechanisms underlying input-specific expression of endocannabinoid-mediated synaptic plasticity in the dorsal cochlear nucleus.Hearing research · 2011Article
- Vesicular glutamate transporters: spatio-temporal plasticity following hearing loss.Neuroscience · 2011Article
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- Cochlear nucleus neurons redistribute synaptic AMPA and glycine receptors in response to monaural conductive hearing loss.Neuroscience · 2009Article
- Dendritic assembly of heteromeric gamma-aminobutyric acid type B receptor subunits in hippocampal neurons.The Journal of biological chemistry · 2009Article
- Distinct functional and anatomical architecture of the endocannabinoid system in the auditory brainstem.Journal of neurophysiology · 2009Article
- Genetic modifiers of Drosophila palmitoyl-protein thioesterase 1-induced degeneration.Genetics · 2007Article
- High-concentration rapid transients of glutamate mediate neural-glial communication via ectopic release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Subthreshold oscillations generated by TTX-sensitive sodium currents in dorsal cochlear nucleus pyramidal cells.Experimental brain research · 2003Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Glutamate receptors are synthesized in the cell body and transported in intracellular compartments to the target synapse. The objective of the present study was to analyze the intracellular pool of glutamate receptors and determine whether the intracellular pool was related to the synaptic distribution of the receptors. As a model system, we chose the fusiform cell of the dorsal cochlear nucleus for which we have previously demonstrated that receptors are selectively targeted to synapses on apical and basal dendrites. A combination of retrograde tracing and postembedding immunogold labeling was used to quantify intracellular receptors in segments of apical and basal dendrites. Immunolabeling for GluR4 and mGluR1alpha is present at synapses on basal dendrites but not on apical dendrites, whereas immunolabeling for GluR2/3 is present at both populations of synapses. In the analysis of intracellular pools, we find that GluR2/3 is equally distributed in apical and basal dendrites, whereas GluR4 and mGluR1alpha are more concentrated in basal dendrites than in apical dendrites. These findings indicate that the distribution of intracellular receptors is related to that of synaptic receptors and suggest that a mechanism exists in neurons to target proteins to dendritic domains soon after synthesis. We found no evidence for the existence of a pool of intracellular receptors, which could represent a receptor reserve, near the postsynaptic density. Receptors were often found in clusters associated with tubulovesicular membranes of the endoplasmic reticulum, identified with immunoglobulin binding protein (BIP) or calnexin, suggesting that this organelle is involved in receptor transport in dendrites.
Indexed as
Identifiers
10377362PMC6782302What OpenQuestion holds
Registered trials
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