ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
113 citing papers in PubMed, 323 citations in OpenAlex.
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- Microglia Colonization Associated with Angiogenesis and Neural Cell Development.Advances in neurobiology · 2024Review
- Identification of ligand-receptor pairs that drive human astrocyte development.Nature neuroscience · 2023Article
- The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130.Molecular neurodegeneration · 2023Article
- Astrocyte development-More questions than answers.Frontiers in cell and developmental biology · 2023Review
- Human stem cell-derived ventral midbrain astrocytes exhibit a region-specific secretory profile.Brain communications · 2023Article
- LIF-IGF Axis Contributes to the Proliferation of Neural Progenitor Cells in Developing Rat Cerebrum.International journal of molecular sciences · 2022Article
- Stepwise pluripotency transitions in mouse stem cells.EMBO reports · 2022Review
- Rare variants and HLA haplotypes associated in patients with neuromyelitis optica spectrum disorders.Frontiers in immunology · 2022Article
- SoxE group transcription factor Sox8 promotes astrocytic differentiation of neural stem/precursor cells downstream of Nfia.Pharmacology research & perspectives · 2021Article
- IL-27 Protects the Brain from Ischemia-Reperfusion Injury via the gp130/STAT3 Signaling Pathway.Journal of molecular neuroscience : MN · 2021Article
- The Role of BMP Signaling in Endothelial Heterogeneity.Frontiers in cell and developmental biology · 2021Review
- MET Receptor Tyrosine Kinase Regulates Lifespan Ultrasonic Vocalization and Vagal Motor Neuron Development.Frontiers in neuroscience · 2021Article
- Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause.Nature communications · 2020Article
- Emerging Roles of Single-Cell Multi-Omics in Studying Developmental Temporal Patterning.International journal of molecular sciences · 2020Review
- The Role of Immune Factors in Shaping Fetal Neurodevelopment.Annual review of cell and developmental biology · 2020Review
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
gp130 is a signal-transducing receptor component used in common by the interleukin-6 (IL-6) family of hematopoietic and neurotrophic cytokines, including IL-6, IL-11, leukemia-inhibitory factor, ciliary neurotrophic factor, oncostatin-M, and cardiotrophin-1. We have examined in this study a role of gp130 in the nervous system by analyzing developmental cell death of several neuronal populations and the differentiation of astrocytes in gp130-deficient mice. A significant reduction was observed in the number of sensory neurons in L5 dorsal root ganglia and motoneurons in the facial nucleus, the nucleus ambiguus, and the lumbar spinal cord in gp130 -/- mice on embryonic day 18.5. On the other hand, no significant neuronal loss was detectable on day 14.5, suggesting a physiological role of gp130 in supporting newly generated neurons during the late phase of development when naturally occurring cell death takes place. Moreover, expression of an astrocyte marker, GFAP, was severely reduced in the brain of gp130 -/- mice. Our data demonstrate that gp130 expression is essential for survival of subgroups of differentiated motor and sensory neurons and for the differentiation of major populations of astrocytes in vivo.
Indexed as
Identifiers
10377352PMC6782325W2104940357What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.