ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 174 citations in OpenAlex.
- Stellate Ganglia and Cardiac Sympathetic Overactivation in Heart Failure.International journal of molecular sciences · 2022Review
- Stem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?Cells · 2021Review
- LianXia Formula Granule Attenuates Cardiac Sympathetic Remodeling in Rats with Myocardial Infarction via the NGF/TrKA/PI3K/AKT Signaling Pathway.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Seasonal Expression of NGF and Its Cognate Receptors in the Ovaries of Grey Squirrels (Animals : an open access journal from MDPI · 2020Article
- p75NTR and DR6 Regulate Distinct Phases of Axon Degeneration Demarcated by Spheroid Rupture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor.Molecular and cellular neurosciences · 2019Article
- ProNGF and Neurodegeneration in Alzheimer's Disease.Frontiers in neuroscience · 2019Review
- Toward the Existence of a Sympathetic Neuroplasticity Adaptive Mechanism Influencing the Immune Response. A Hypothetical View-Part I.Frontiers in endocrinology · 2019Article
- Recent advances in understanding context-dependent mechanisms controlling neurotrophin signaling and function.F1000Research · 2019Review
- Villainous role of estrogen in macrophage-nerve interaction in endometriosis.Reproductive biology and endocrinology : RB&E · 2018Review
- Implication of the neurotrophin receptor p75Expert review of ophthalmology · 2017Article
- Early sympathetic islet neuropathy in autoimmune diabetes: lessons learned and opportunities for investigation.Diabetologia · 2016Review
- Molecular Mechanisms of Sympathetic Remodeling and Arrhythmias.Circulation. Arrhythmia and electrophysiology · 2016Review
- Recent advances in understanding neurotrophin signaling.F1000Research · 2016Review
- Article
- Coronin-1 and calcium signaling governs sympathetic final target innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Estrogen and female reproductive tract innervation: cellular and molecular mechanisms of autonomic neuroplasticity.Autonomic neuroscience : basic & clinical · 2015Review
- The peritoneum--an important factor for pathogenesis and pain generation in endometriosis.Journal of molecular medicine (Berlin, Germany) · 2014Review
- The nerve growth factor signaling and its potential as therapeutic target for glaucoma.BioMed research international · 2014Review
- Sympathetic denervation of peri-infarct myocardium requires the p75 neurotrophin receptor.Experimental neurology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this report, we provide evidence that NGF and BDNF have functionally antagonistic actions on sympathetic neuron growth and target innervation, with NGF acting via TrkA to promote growth and BDNF via p75NTR to inhibit growth. Specifically, in cultured sympathetic neurons that themselves synthesize BDNF, exogenous BDNF inhibits and function-blocking BDNF antibodies enhance process outgrowth. Both exogenous and autocrine BDNF mediate this effect via p75NTR because (1) BDNF does not inhibit growth of neurons lacking p75NTR, (2) function-blocking p75NTR antibodies enhance NGF-mediated growth, and (3) p75NTR-/- sympathetic neurons grow more robustly in response to NGF than do their wild-type counterparts. To determine the physiological relevance of this functional antagonism, we examined the pineal gland, a well defined sympathetic target organ. BDNF is present in the pineal gland during target innervation, and incoming sympathetic axons are p75NTR positive. Moreover, the pineal glands of BDNF+/- and BDNF-/- mice are hyperinnervated with sympathetic fibers, and tyrosine hydroxylase (TH) levels are elevated. Increased tyrosine hydroxylase is also observed in the BDNF+/- carotid artery, another sympathetic neuron target. Thus, BDNF, made by sympathetic neurons and/or their target organs, acts via p75NTR to antagonize NGF-mediated growth and target innervation, suggesting that sympathetic target innervation is determined by the balance of positively and negatively acting neurotrophins present in developing and potentially mature targets.
Indexed as
Identifiers
10377349PMC6782315W1855182844What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.