ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 138 citations in OpenAlex.
- C5a Induces Inflammatory Signaling and Apoptosis in PC12 Cells through C5aR-Dependent Signaling: A Potential Mechanism for Adrenal Damage in Sepsis.International journal of molecular sciences · 2024Article
- High-intensity interval training combined with cannabidiol supplementation improves cognitive impairment by regulating the expression of apolipoprotein E, presenilin-1, and glutamate proteins in a rat model of amyloid β-induced Alzheimer's disease.Iranian journal of basic medical sciences · 2024Article
- Glycogen synthase kinase 3β (GSK3β) and presenilin (PS) are key regulators of kinesin-1-mediated cargo motility within axons.Frontiers in cell and developmental biology · 2023Review
- Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease.Neural regeneration research · 2022Article
- Neuroprotective effects of ZL006 in AβNeural regeneration research · 2020Article
- Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease.Molecular brain · 2019Review
- Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively.The Journal of biological chemistry · 2015Article
- CDK5 activator protein p25 preferentially binds and activates GSK3β.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells.BMC biochemistry · 2012Article
- Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.Neuron · 2011Article
- Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway.International journal of Alzheimer's disease · 2011Article
- Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3.International journal of Alzheimer's disease · 2011Article
- Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease.Molecular neurodegeneration · 2010Article
- Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice.Journal of neuroscience research · 2010Article
- Neurogenesis and Alzheimer's disease: at the crossroads.Experimental neurology · 2010Review
- Article
- Low density lipoprotein receptor-related protein 1 promotes anti-apoptotic signaling in neurons by activating Akt survival pathway.The Journal of biological chemistry · 2009Article
- The molecular programme of tumour reversion: the steps beyond malignant transformation.Nature reviews. Cancer · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Most early onset cases of familial Alzheimer's disease (AD) are caused by mutations in presenilin-1 (PS1) and presenilin-2 (PS2). These mutations lead to increased beta-amyloid formation and may induce apoptosis in some model systems. Using primary cultured hippocampal neurons (HNs) and rat pheochromocytoma (PC12) cells transiently transfected with replication-defective recombinant adenoviral vectors expressing wild-type or mutant PS1, we demonstrate that mutant PS1s induce apoptosis, downregulate the survival factor Akt/PKB, and affect several Akt/PKB downstream targets, including glycogen synthase kinase-3beta and beta-catenin. Expression of a constitutively active Akt/PKB rescues HNs from mutant PS1-induced neuronal cell death, suggesting a potential therapeutic target for AD. Downregulation of Akt/PKB may be a mechanism by which mutant PS1 induces apoptosis and may play a role in the pathogenesis of familial AD.
Indexed as
Identifiers
10377346PMC6782321W1799837960What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.