ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Calcium-activated potassium conductances contribute to action potential repolarization at the soma but not the dendrites of hippocampal CA1 pyramidal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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Who cites it
48 citing papers in PubMed, 108 citations in OpenAlex.
- Dendritic interaction of timescales in afterdepolarization potentials and nonmonotonic spike-adding.Journal of computational neuroscience · 2026Article
- How to train your neuron: developing a detailed, up-to-date, multipurpose model of hippocampal CA1 pyramidal cells.Frontiers in computational neuroscience · 2026Article
- CaInternational journal of molecular sciences · 2023Review
- Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus.Frontiers in cellular neuroscience · 2019Article
- Increased transient NaThe Journal of physiology · 2017Article
- Roles of specific Kv channel types in repolarization of the action potential in genetically identified subclasses of pyramidal neurons in mouse neocortex.Journal of neurophysiology · 2016Article
- The Impact of BK Channels on Cellular Excitability Depends on their Subcellular Location.Frontiers in cellular neuroscience · 2016Article
- BK Channels in the Central Nervous System.International review of neurobiology · 2016Review
- Analogous synaptic plasticity profiles emerge from disparate channel combinations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Postsynaptic adenosine A2A receptors modulate intrinsic excitability of pyramidal cells in the rat basolateral amygdala.The international journal of neuropsychopharmacology · 2015Article
- BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons.Brain research · 2014Article
- Characteristics of single large-conductance Ca2+-activated K+ channels and their regulation of action potentials and excitability in parasympathetic cardiac motoneurons in the nucleus ambiguus.American journal of physiology. Cell physiology · 2014Article
- Habituation of reflexive and motivated behavior in mice with deficient BK channel function.Frontiers in integrative neuroscience · 2013Article
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- New rules governing synaptic plasticity in core nucleus accumbens medium spiny neurons.The European journal of neuroscience · 2012Article
- Dendritic ion channelopathy in acquired epilepsy.Epilepsia · 2012Review
- Acute stress induces down-regulation of large-conductance Ca2+-activated potassium channels in the lateral amygdala.The Journal of physiology · 2012Article
- Targeting BK (big potassium) channels in epilepsy.Expert opinion on therapeutic targets · 2011Review
- Enhancement effects of martentoxin on glioma BK channel and BK channel (α+β1) subtypes.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Evidence is accumulating that voltage-gated channels are distributed nonuniformly throughout neurons and that this nonuniformity underlies regional differences in excitability within the single neuron. Previous reports have shown that Ca2+, Na+, A-type K+, and hyperpolarization-activated, mixed cation conductances have varying distributions in hippocampal CA1 pyramidal neurons, with significantly different densities in the apical dendrites compared with the soma. Another important channel mediates the large-conductance Ca2+-activated K+ current (IC), which is responsible in part for repolarization of the action potential (AP) and generation of the afterhyperpolarization that follows the AP recorded at the soma. We have investigated whether this current is activated by APs retrogradely propagating in the dendrites of hippocampal pyramidal neurons using whole-cell dendritic patch-clamp recording techniques. We found no IC activation by back-propagating APs in distal dendritic recordings. Dendritic APs activated IC only in the proximal dendrites, and this activation decayed within the first 100-150 micrometer of distance from the soma. The decay of IC in the proximal dendrites occurred despite AP amplitude, plus presumably AP-induced Ca2+ influx, that was comparable with that at the soma. Thus we conclude that IC activation by action potentials is nonuniform in the hippocampal pyramidal neuron, which may represent a further example of regional differences in neuronal excitability that are determined by the nonuniform distribution of voltage-gated channels in dendrites.
Indexed as
Identifiers
10377332PMC6782335W2142131601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.