ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
A zinc-dependent Cl- current in neuronal somata.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- The Function and Regulation of Zinc in the Brain.Neuroscience · 2021Review
- Zinc in the Brain: Friend or Foe?International journal of molecular sciences · 2020Review
- Review: Zinc's functional significance in the vertebrate retina.Molecular vision · 2014Review
- Zinc modulation of basal and β-adrenergically stimulated L-type Ca2+ current in rat ventricular cardiomyocytes: consequences in cardiac diseases.Pflugers Archiv : European journal of physiology · 2012Article
- Zinc is both an intracellular and extracellular regulator of KATP channel function.The Journal of physiology · 2004Article
- Dissociation of retinal ganglion cells without enzymes.Journal of neuroscience methods · 2004Article
- Availability of low-threshold Ca2+ current in retinal ganglion cells.Journal of neurophysiology · 2003Article
- A dopamine- and protein kinase A-dependent mechanism for network adaptation in retinal ganglion cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Deactivation, recovery from inactivation, and modulation of extra-synaptic ion currents in fish retinal ganglion cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Extracellular Zn2+ modulates current passage through voltage- and neurotransmitter-gated ion channels, at concentrations less than, or near, those produced by release at certain synapses. Electrophysiological effects of cytoplasmic Zn2+ are less well understood, and effects have been observed at concentrations that are orders of magnitude greater than those found in resting and stimulated neurons. To examine whether and how neurons are affected by lower levels of cytoplasmic Zn2+, we tested the effect of Zn2+-selective chelators, Zn2+-preferring ionophores, and exogenous Zn2+ on neuronal somata during whole-cell patch-clamp recordings. We report here that cytoplasmic zinc facilitates the downward regulation of a background Cl- conductance by an endogenous protein kinase C (PKC) in fish retinal ganglion cell somata and that this regulation is maintained if nanomolar levels of free Zn2+ are available. This regulation has not been described previously in any tissue, as other Cl- currents have been described as reduced by PKC alone, reduced by Zn2+ alone, or reduced by both independently. Moreover, control of cation currents by a zinc-dependent PKC has not been reported previously. The regulation we have observed thus provides the first electrophysiological measurements consistent with biochemical measurements of zinc-dependent PKC activity in other systems. These results suggest that contributions of background Cl- conductances to electrical properties of neurons are susceptible to modulation.
Indexed as
Identifiers
10377331PMC6782341W1955565432What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.