ArticleThe Journal of clinical investigation1999
Short ragweed allergen induces eosinophilic lung disease in HLA-DQ transgenic mice.
Article in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins.Frontiers in immunology · 2023Article
- Are We Meeting the Promise of Endotypes and Precision Medicine in Asthma?Physiological reviews · 2020Review
- The genetic and epigenetic landscapes of the epithelium in asthma.Respiratory research · 2016Review
- Article
- Neuroimmune semaphorin 4A as a drug and drug target for asthma.International immunopharmacology · 2013Article
- STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- IL-13 and STAT6 signaling involve in low dose lipopolysaccharide induced murine model of asthma.Asia Pacific allergy · 2013Article
- STAT4-dependent and -independent Th2 responses correlate with protective immunity against lung infection with Pneumocystis murina.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Neuroimmune semaphorin 4A downregulates the severity of allergic response.Mucosal immunology · 2012Article
- Article
- Expression of neuroimmune semaphorins 4A and 4D and their receptors in the lung is enhanced by allergen and vascular endothelial growth factor.BMC immunology · 2011Article
- STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Identification of antigenic epitopes on human allergens: studies with HLA transgenic mice.Environmental health perspectives · 2003Article
- HLA class II polymorphism influences onset and severity of pathology in Schistosoma mansoni-infected transgenic mice.Infection and immunity · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
The human leukocyte antigen (HLA) restriction of the IgE response to different allergens in humans has been a subject of numerous published studies. However, the role and contribution of specific HLA class II molecules in the pathogenesis of allergic airway inflammation are unknown and difficult to assess. HLA-DQ6 and HLA-DQ8 transgenic mice lacking endogenous mouse class II gene expression were actively immunized and later challenged intranasally with short ragweed (SRW) allergenic extract. The HLA-DQ transgenic mice developed pulmonary eosinophilia and lung tissue damage. We also found an increase in total protein (TP) level and IL-5 production in bronchoalveolar lavage (BAL) fluid and an increase in SRW-specific Th2-type immunoglobulins (IgG1, IgG2b) and total serum IgE levels. Under similar treatment, DQ-negative full-sib control mice were normal. The allergic response could be significantly inhibited or abrogated in HLA-DQ mice by systemic treatment with anti-DQ mAb. The in vivo responses of HLA-DQ6 and HLA-DQ8 mice showed differences in terms of levels of eosinophilia, BAL protein, IL-5 concentration, and lung hyperreactivity to inhaled methacholine. These findings demonstrate the crucial role for specific HLA-DQ molecules in SRW-specific CD4(+) T-cell activation and resulting recruitment of eosinophils into the airways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.