ArticleThe Journal of clinical investigation1999
Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension.
Article in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- A systematic review and meta-analysis on the association between CD36 rs1761667 polymorphism and cardiometabolic risk factors in adults.Scientific reports · 2022Pooled it
- Differences in mRNA Expression of Selected Cytochrome P450, Transporters and Nuclear Receptors Among Various Rat Models of Metabolic Syndrome.Basic & clinical pharmacology & toxicology · 2025Article
- CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study.PloS one · 2023Article
- Nutrigenetic Interaction of Spontaneously Hypertensive Rat Chromosome 20 Segment and High-Sucrose Diet Sensitizes to Metabolic Syndrome.Nutrients · 2022Article
- Genetic Complementation of ATP Synthase Deficiency Due to Dysfunction of TMEM70 Assembly Factor in Rat.Biomedicines · 2022Article
- Downregulation of theAntioxidants (Basel, Switzerland) · 2020Article
- Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications.Scientific reports · 2019Article
- Systems genetic analysis of brown adipose tissue function.Physiological genomics · 2018Article
- Genetics of hypertension: an assessment of progress in the spontaneously hypertensive rat.Physiological genomics · 2017Review
- Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.Physiological reviews · 2017Review
- Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat.Disease models & mechanisms · 2017Article
- Genome-wide identification of long noncoding RNAs in rat models of cardiovascular and renal disease.Hypertension (Dallas, Tex. : 1979) · 2015Article
- NPY and NPY receptors in airway structural and inflammatory cells in allergic asthma.Experimental and molecular pathology · 2013Article
- CD36 as a therapeutic target for endothelial dysfunction in stroke.Current pharmaceutical design · 2012Review
- Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.Physiological genomics · 2011Article
- Role of FAT/CD36 in novel PKC isoform activation in heart of spontaneously hypertensive rats.Molecular and cellular biochemistry · 2011Article
- Preliminary studies on CD36 gene in type 2 diabetic patients from north India.The Indian journal of medical research · 2011Article
- Recent advances in genetics of the spontaneously hypertensive rat.Current hypertension reports · 2010Review
- Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat.Hypertension (Dallas, Tex. : 1979) · 2009Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 3 countries.
Funding
Abstract
Disorders of carbohydrate and lipid metabolism have been reported to cluster in patients with essential hypertension and in spontaneously hypertensive rats (SHRs). A deletion in the Cd36 gene on chromosome 4 has recently been implicated in defective carbohydrate and lipid metabolism in isolated adipocytes from SHRs. However, the role of Cd36 and chromosome 4 in the control of blood pressure and systemic cardiovascular risk factors in SHRs is unknown. In the SHR. BN-Il6/Npy congenic strain, we have found that transfer of a segment of chromosome 4 (including Cd36) from the Brown Norway (BN) rat onto the SHR background induces reductions in blood pressure and ameliorates dietary-induced glucose intolerance, hyperinsulinemia, and hypertriglyceridemia. These results demonstrate that a single chromosome region can influence a broad spectrum of cardiovascular risk factors involved in the hypertension metabolic syndrome. However, analysis of Cd36 genotypes in the SHR and stroke-prone SHR strains indicates that the deletion variant of Cd36 was not critical to the initial selection for hypertension in the SHR model. Thus, the ability of chromosome 4 to influence multiple cardiovascular risk factors, including hypertension, may depend on linkage of Cd36 to other genes trapped within the differential segment of the SHR. BN-Il6/Npy strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.