ArticleInfection and immunity1999
Human monocytic U937 cells kill Salmonella in vitro by NO-independent mechanisms.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- HLA-B27 Correlates with the Intracellular Elimination, Replication, and Trafficking of Salmonella Enteritidis Collected from Reactive Arthritis Patients.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Article
- Microarray analysis of response of Salmonella during infection of HLA-B27- transfected human macrophage-like U937 cells.BMC genomics · 2010Article
- Analysis of nitric oxide-dependent antimicrobial actions in macrophages and mice.Methods in enzymology · 2008Review
- N(2)O(3) enhances the nitrosative potential of IFNgamma-primed macrophages in response to Salmonella.Immunobiology · 2007Article
- The role of infection in the pathogenesis of spondyloarthropathies with special reference to human leukocyte antigen-B27.Current rheumatology reports · 2002Review
- Nitric oxide metabolites in gnotobiotic piglets orally infected with Salmonella enterica serovar typhimurium.Folia microbiologica · 2001Article
- Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro.The Journal of experimental medicine · 2000Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) has a central role in host defense against intracellular microbes. HLA-B27 has been shown to directly modulate host-microbe interaction in vitro, leading to the impaired elimination of Salmonella in human monocytic U937 cells. Here, we studied whether impaired elimination of Salmonella would result from differences in NO production between HLA-B27- and HLA-A2-transfected U937 cells. Both human monocytic transfectants produced NO equally well and killed Salmonella via NO-independent mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.