ArticleInfection and immunity1999
Role of superoxide dismutase activity in the physiology of Porphyromonas gingivalis.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis.Clinical and experimental dental research · 2026Review
- Stimuli-responsive, antimicrobial-loaded nanocarriers for oral biofilm control and microbiome restoration.International journal of oral science · 2026Review
- 3D Peri-Implant Epi-Mucosa-on-a-Chip Reveals Alterations in Epithelial Barrier Function Mediated by Host-Bacteria-Biomaterial Interactions.ACS biomaterials science & engineering · 2025Article
- Defining the role of Hmu and Hus systems in Porphyromonas gingivalis heme and iron homeostasis and virulence.Scientific reports · 2024Article
- Old dogs, new tricks: New insights into the iron/manganese superoxide dismutase family.Journal of inorganic biochemistry · 2022Article
- In vivo expression of proteases and protease inhibitor, a serpin, by periodontal pathogens at teeth and implants.Molecular oral microbiology · 2018Article
- Macrophage Polarization Alters Postphagocytosis Survivability of the Commensal Streptococcus gordonii.Infection and immunity · 2018Article
- Article
- Modulation of Neutrophil Extracellular Trap and Reactive Oxygen Species Release by Periodontal Bacteria.Infection and immunity · 2017Article
- Proteomic analysis reveals that a global response is induced by subinhibitory concentrations of ampicillin.Bioengineered · 2017Article
- Veillonella Catalase Protects the Growth of Fusobacterium nucleatum in Microaerophilic and Streptococcus gordonii-Resident Environments.Applied and environmental microbiology · 2017Article
- Bactericidal effects of 310 nm ultraviolet light-emitting diode irradiation on oral bacteria.BMC oral health · 2017Article
- Pathways that Regulate ROS Scavenging Enzymes, and Their Role in Defense Against Tissue Destruction in Periodontitis.Frontiers in physiology · 2017Review
- The role of heme binding by DNA-protective protein from starved cells (Dps) in the Tolerance of Porphyromonas gingivalis to heme toxicity.The Journal of biological chemistry · 2012Article
- OxyR activation in Porphyromonas gingivalis in response to a hemin-limited environment.Infection and immunity · 2012Article
- DNA repair of 8-oxo-7,8-dihydroguanine lesions in Porphyromonas gingivalis.Journal of bacteriology · 2008Article
- Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis.Frontiers in bioscience : a journal and virtual library · 2008Review
- OxyR is involved in coordinate regulation of expression of fimA and sod genes in Porphyromonas gingivalis.FEMS microbiology letters · 2008Article
- Effects of various growth conditions in a chemostat on expression of virulence factors in Porphyromonas gingivalis.Applied and environmental microbiology · 2006Article
- Role of oxyR in the oral anaerobe Porphyromonas gingivalis.Journal of bacteriology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Porphyromonas gingivalis is a gram-negative, obligate anaerobe strongly associated with chronic adult periodontitis. A previous study has demonstrated that this organism requires superoxide dismutase (SOD) for its modest aerotolerance. In this study, we have constructed a mutant deficient in SOD activity by insertional inactivation as well as a sod::lacZ reporter translational fusion construct to study the regulation of expression of this gene. We have confirmed that SOD is essential for tolerance to atmospheric oxygen but does not appear to be protective against hydrogen peroxide or exogenously generated reactive oxygen species. Furthermore, the sod mutant appeared to be no more sensitive to killing by neutrophils than the parental strain 381. SOD appears to be protective against oxygen-dependent DNA damage as measured by increased mutation to rifampin resistance by the sod mutant. Use of the sod::lacZ construct confirmed that SOD expression is maximal at mid-log phase and is influenced by oxygen, temperature, and pH. However, expression does not appear to be significantly affected by iron depletion, osmolarity, or nutrient depletion. The transcription start site of the sod gene was determined to be 315 bp upstream of the sod start codon and to be within an upstream open reading frame. Our studies demonstrate the essential role that SOD plays in aerotolerance of this organism as well as the selective induction of this enzyme by environmental stimuli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.