ArticleInfection and immunity1999
Coxiella burnetii infection increases transferrin receptors on J774A. 1 cells.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- TGF-β/IFN-γ Antagonism in Subversion and Self-Defense of Phase II Coxiella burnetiiInfection and immunity · 2023Trial
- Article
- Article
- High-Content Imaging Reveals Expansion of the Endosomal Compartment duringFrontiers in cellular and infection microbiology · 2017Article
- Metabolic host responses to infection by intracellular bacterial pathogens.Frontiers in cellular and infection microbiology · 2013Review
- Modulation of iron homeostasis in macrophages by bacterial intracellular pathogens.BMC microbiology · 2010Article
- Limited transcriptional responses of Rickettsia rickettsii exposed to environmental stimuli.PloS one · 2009Article
- Limited role for iron regulation in Coxiella burnetii pathogenesis.Infection and immunity · 2008Article
- Sustained axenic metabolic activity by the obligate intracellular bacterium Coxiella burnetii.Journal of bacteriology · 2008Article
- Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study.Respiratory research · 2008Article
- Temporal analysis of Coxiella burnetii morphological differentiation.Journal of bacteriology · 2004Article
- Transferrin receptor induction in Toxoplasma gondii-infected HFF is associated with increased iron-responsive protein 1 activity and is mediated by secreted factors.Parasitology research · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Inoculation with viable, but not inactivated, Coxiella burnetii resulted in the increased expression of transferrin receptors (TfR) in the murine macrophage-like cell line J774A.1. This upregulation was evident in immunoblots as early as 6 h postinfection, with TfR levels continuing to increase through the first 24 h of infection. Fluorescent labeling revealed that TfR upregulation occurred throughout infected monolayers, eliminating the possibility that it reflected a response by a minor subset of host cells. In addition, TfR trafficking did not appear to be affected by C. burnetii infection. Consistent with the increase in TfRs, inoculation with viable C. burnetii resulted in a 2.5-fold increase in total cellular iron by 12 h postinoculation. Our further findings that the chelation of intracellular iron arrests C. burnetii replication and that C. burnetii metabolic activities in vitro are affected by iron concentration suggest that TfR upregulation is a salient factor in C. burnetii infection, and we speculate that it may represent a significant virulence mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.