ArticleOncogene1999
Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 117 citations in OpenAlex.
- ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author.Journal of mammary gland biology and neoplasia · 2023Review
- Busting the Breast Cancer with AstraZeneca's Gefitinib.Advances in pharmacological and pharmaceutical sciences · 2023Review
- Review
- Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine.Nature communications · 2018Article
- ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation.Breast cancer research : BCR · 2017Article
- Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.Journal of cell science · 2016Article
- RNA-Seq reveals 10 novel promising candidate genes affecting milk protein concentration in the Chinese Holstein population.Scientific reports · 2016Article
- The transcriptional repressor Blimp1 is expressed in rare luminal progenitors and is essential for mammary gland development.Development (Cambridge, England) · 2016Article
- Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model.Frontiers in pharmacology · 2016Review
- Fatty acid synthase is required for mammary gland development and milk production during lactation.American journal of physiology. Endocrinology and metabolism · 2014Article
- Article
- Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways.Genes & development · 2012Article
- Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models.BMC medicine · 2012Article
- Evaluation of HER2 gene amplification in breast cancer using nuclei microarray in situ hybridization.International journal of molecular sciences · 2012Article
- Targeting HER2 in breast cancer: overview of long-term experience.International journal of women's health · 2010Article
- ERBB3/HER3 and ERBB2/HER2 duet in mammary development and breast cancer.Journal of mammary gland biology and neoplasia · 2008Review
- The ADAM17-amphiregulin-EGFR axis in mammary development and cancer.Journal of mammary gland biology and neoplasia · 2008Review
- ErbB3 is required for ductal morphogenesis in the mouse mammary gland.Breast cancer research : BCR · 2008Article
- Vaccines for tumour prevention.Nature reviews. Cancer · 2006Review
- The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.Breast cancer research : BCR · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Overexpression of the receptor tyrosine kinase ErbB2/HER2/Neu (ErbB2) occurs in 15-40% of human breast cancers. To determine the function of ErbB2 signaling during normal mouse mammary gland development, we expressed a carboxyl-terminal truncated dominant negative allele of ErbB2 (ErbB2deltaIC) in the developing mouse mammary gland. Despite ErbB2deltaIC expression within mammary glands of pubescent virgin and pregnant mice, a phenotype was not observed until late in pregnancy. At 1 day post-partum, lactationally active, distended lobuloalveoli failed to form. This phenotype was exaggerated in multiparous females expressing ErbB2deltaIC. Immunohistochemical staining for ErbB2deltaIC revealed a concordance between high levels of ErbB2deltaIC protein expression and the absence of lactational products within the lumens of ErbB2deltaIC stained lobuloalveoli. These results demonstrate that ErbB2 signaling is required for proper mammary development and lactation at parturition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.