ArticleArchives of disease in childhood. Fetal and neonatal edition1999
Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy.
Article in Archives of disease in childhood. Fetal and neonatal edition, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 4 of them syntheses that pooled it.
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Who cites it
96 citing papers in PubMed, 4 syntheses or guidelines pooled it, 437 citations in OpenAlex.
- Pooled it
- Paradigm shifts in neonatal hypoxic-ischemic encephalopathy therapeutics: a four-decade bibliometric exploration of emerging therapeutic dimensions (1985-2024).Frontiers in pediatrics · 2025Pooled it
- Predictive value of amplitude-integrated EEG (aEEG) after rescue hypothermic neuroprotection for hypoxic ischemic encephalopathy: a meta-analysis.Journal of perinatology : official journal of the California Perinatal Association · 2017Pooled it
- Amplitude Integrated Electroencephalogram as a Prognostic Tool in Neonates with Hypoxic-Ischemic Encephalopathy: A Systematic Review.PloS one · 2016Pooled it
- Early clinical signs in neonates with hypoxic ischemic encephalopathy predict an abnormal amplitude-integrated electroencephalogram at age 6 hours.BMC pediatrics · 2013Trial
- Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial.The Lancet. Neurology · 2010Trial
- Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia.Archives of disease in childhood. Fetal and neonatal edition · 2006Trial
- Neonatal Epilepsy: Beyond Seizures in a Developing Brain-A Narrative Review.Brain sciences · 2026Review
- Long-Term Neurodevelopmental Outcomes and Prognostic Factors in Neonates with Hypoxic-Ischemic Encephalopathy.Journal of clinical medicine · 2026Article
- Early outcome-prediction with an automated EEG background trend in hypothermia-treated newborns with encephalopathy.Pediatric research · 2026Article
- Different Patterns of Cortical Electrical Activity by Tactile, Acoustic and Visual Stimuli in Infants: An EEG Exploratory Study.Diagnostics (Basel, Switzerland) · 2025Article
- Day-2 echocardiography and cardiovascular biomarkers measurements in neonates with hypoxic-ischemic encephalopathy with or without brain injury.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Cardiac function at follow-up in infants treated with therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy.Pediatric research · 2025Article
- Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in Sub-Saharan Africa: A scoping review.PloS one · 2025Article
- Minimal impact of feed intolerance during therapeutic hypothermia for hypoxic ischaemic encephalopathy in a South African cohort with a standardised feeding regimen.Frontiers in pediatrics · 2025Article
- Intermittent theta-burst stimulation alleviates hypoxia-ischemia-caused myelin damage and neurologic disability.Experimental neurology · 2024Article
- Knowledge mapping of neonatal electroencephalogram: A bibliometric analysis (2004-2022).Brain and behavior · 2024Article
- Neuromonitoring During ECMO Support in Children.Neurocritical care · 2023Review
- Neuromonitoring in neonatal critical care part I: neonatal encephalopathy and neonates with possible seizures.Pediatric research · 2023Review
- Technical feasibility of multimodal imaging in neonatal hypoxic-ischemic encephalopathy from an ovine model to a human case series.Frontiers in pediatrics · 2023Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the prognostic value of amplitude integrated EEG (aEEG) 3 and 6 hours after birth.
methodsSeventy three term, asphyxiated infants were studied (from two different centres), using the Cerebral Function Monitor (CFM Lectromed). The different aEEG tracings were compared using pattern recognition (flat tracing mainly isoelectric (FT); continuous extremely low voltage (CLV); burst-suppression (BS); discontinuous normal voltage (DNV); continuous normal voltage (CNV)) with subsequent outcome.
resultsSixty eight infants were followed up for more than 12 months (range 12 months to 6 years). Twenty one out of 68 infants (31%) showed a change in pattern from 3 to 6 hours, but this was only significant in five cases (24%). In three this changed from BS to CNV with a normal outcome. One infant showed a change in pattern from CNV to FT and had a major handicap at follow up. Another infant showed a change in pattern from DNV to BS, and developed a major handicap at follow up. The other 16 infants did not have any significant changes in pattern: 11 infants had CLV, BS, or FT at 3 and 6 hours and died (n = 9) in the neonatal period or developed a major handicap (n = 2). Five infants had a CNV or DNV pattern at 3 and 6 hours, with a normal outcome. The sensitivity and specificity of BS, together with FT and CLV, for poor outcome at 3 hours was 0.85 and 0.77, respectively; at 6 hours 0.91 and 0.86, respectively. The positive predictive value (PPV) was 78% and the negative predictive value (NPV) 84% 3 hours after birth. At 6 hours the PPV was 86% and the NPV was 91%.
conclusionaEEG could be very useful for selecting those infants who might benefit from intervention after birth asphyxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.