Evidence map›Paper›PMID 10374695›Full record

ReviewImmunologic research1999

Negative signaling in health and disease.

K M Coggeshall

Abstract readReview
PubMed Publisher
In one paragraph

Review in Immunologic research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

K M CoggeshallDepartment of Microbiology and the Comprehensive Cancer Center, Ohio State University, Columbus 43210, USA. coggeshall.1@osu.edu
The Ohio State University · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
PHOSPHATIDYLINOSITOL 3 KINASE IN B CELL ACTIVATIONR01CA064268 · NCI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI COGGESHALL, KENNETH MARK · 1999 to 2003
$1.0M
BIOCHEMISTRY OF B LYMPHOCYTE NEGATIVE SIGNALINGR01AI041447 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI COGGESHALL, KENNETH MARK · 1997 to 1999
–
REGULATION OF RAS ACTIVITY IN B LYMPHOCYTESR29CA064268 · NCI · OHIO STATE UNIVERSITY · PI COGGESHALL, KENNETH MARK · 1994 to 1998
–
NCI NIH HHS CA64268NCI NIH HHS P30 CA16058NIAID NIH HHS AI41447
6 · The paper itself

Abstract

Signal transduction induced by receptors can elicit intracellular biochemical events that either support or inhibit cell activation. Induction of the latter has been termed "negative signaling" and can be triggered by receptors on immune cells that are distinct from activating receptors while other growth-promoting receptors induce both positive and negative signaling events. Here, the biochemistry leading to cell activation or inhibition and induced by receptors on immune cells are reviewed. Furthermore, recent experimental evidence is reviewed that indicates an important contribution of negative signaling to the intracellular survival of infectious pathogens.

Indexed as

Signal TransductionB-LymphocytesHumansInfectionsIntracellular Signaling Peptides and ProteinsLymphocyte ActivationPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphoric Monoester HydrolasesProtein Tyrosine Phosphatase, Non-Receptor Type 11Protein Tyrosine Phosphatase, Non-Receptor Type 6Protein Tyrosine PhosphatasesReceptors, Antigen, B-CellReceptors, ImmunologicINPPL1 protein, humanIntracellular Signaling Peptides and ProteinsPhosphatidylinositol-3,4,5-Trisphosphate 5-PhosphatasesPhosphoric Monoester HydrolasesProtein Tyrosine Phosphatase, Non-Receptor Type 11Protein Tyrosine Phosphatase, Non-Receptor Type 6Protein Tyrosine PhosphatasesPTPN11 protein, humanPTPN6 protein, humanReceptors, Antigen, B-CellReceptors, Immunologic

Identifiers

PMID10374695
OpenAlexW2139453887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.