Trial reportThe Journal of physiology1999
Changes in excitability indices of cutaneous afferents produced by ischaemia in human subjects.
Trial report in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Responses of human sensory and motor axons to the release of ischaemia and to hyperpolarizing currents.The Journal of physiology · 2002Trial
- Acute Foot Warming Enhances Plantar Tactile Sensitivity With Limited Postural Control Effects in Obese Older Adults.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Article
- Fatigue and activity-dependent conduction block in neuromuscular disorders.Clinical neurophysiology practice · 2022Article
- Axonal Excitability in Amyotrophic Lateral Sclerosis : Axonal Excitability in ALS.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability.Intensive care medicine experimental · 2016Article
- Article
- Dynamic changes in the perceived posture of the hand during ischaemic anaesthesia of the arm.The Journal of physiology · 2011Article
- Changes in human sensory axonal excitability induced by focal nerve compression.The Journal of physiology · 2010Article
- Local antinociception induced by endothelin-1 in the hairy skin of the rat's back.The journal of pain · 2009Article
- Differences in activity-dependent hyperpolarization in human sensory and motor axons.The Journal of physiology · 2004Article
- Sodium channel function and the excitability of human cutaneous afferents during ischaemia.The Journal of physiology · 2002Article
- Voluntary contraction impairs the refractory period of transmission in healthy human axons.The Journal of physiology · 2001Article
- Ischaemic changes in refractoriness of human cutaneous afferents under threshold-clamp conditions.The Journal of physiology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The present study was undertaken to determine whether mechanisms other than membrane depolarization contribute to the changes in excitability of cutaneous afferents of the median nerve under ischaemic conditions. 2. In six healthy subjects, axonal excitability was measured as the reciprocal of the threshold for a compound sensory action potential (CSAP) of 50% maximal amplitude. Refractoriness and supernormality were measured as threshold changes 2 and 7 ms, respectively, after supramaximal conditioning stimuli. The strength-duration time constant (tauSD) was calculated from the thresholds for unconditioned CSAPs using test stimuli of 0.1 and 1.0 ms duration. Changes in these indices were measured when subthreshold polarizing currents lasting 10 or 100 ms were applied, before, during and after ischaemia for 13 min. 3. At rest, the change in supernormality produced by polarizing currents was greater with the longer polarizing current, indicating that it took up to 100 ms to charge the internodal capacitance. 4. Refractoriness and its dependence on excitability increased more than expected during ischaemia. Supernormality was abolished during ischaemia, and reached a maximum after ischaemia but was then barely altered by polarizing current. tauSD had a similar relationship to excitability before, during and after ischaemia. 5. By contrast, during continuous depolarizing current for 8 min to mimic the depolarization produced by ischaemia, the relationship between excitability and refractoriness was the same during the depolarization as before it. 6. It is suggested that the large increase in refractoriness during ischaemia might be due to interference with the recovery from inactivation of transient sodium channels by an intra-axonal substrate of ischaemia. The post-ischaemic increase in supernormality and the lack of change with changes in axonal excitability can be explained by blockage of voltage-dependent potassium channels.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.