ArticleNucleic acids research1999
RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver.
Article in Nucleic acids research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Functional polymorphisms in the CYP2C19 gene contribute to digestive system cancer risk: evidence from 11,042 subjects.PloS one · 2013Pooled it
- Circular and Fusion RNAs in Medulloblastoma Development.Cancers · 2022Article
- Chimeric RNAs and their implications in cancer.Current opinion in genetics & development · 2018Review
- The Landscape of long noncoding RNA classification.Trends in genetics : TIG · 2015Review
- Short homologous sequences are strongly associated with the generation of chimeric RNAs in eukaryotes.Journal of molecular evolution · 2009Article
- Transcription-mediated gene fusion in the human genome.Genome research · 2006Article
- Tandem chimerism as a means to increase protein complexity in the human genome.Genome research · 2006Article
- Establishment of a transgenic cell line stably expressing human cytochrome P450 2C18 and identification of a CYP2C18 clone with exon 5 missing.World journal of gastroenterology · 2002Article
- Clinical significance of the cytochrome P450 2C19 genetic polymorphism.Clinical pharmacokinetics · 2002Review
- Article
- Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4.BMC genomics · 2001Article
- Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing.Gene therapy · 2000Article
- Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene.Genome research · 2000Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reverse transcription-PCR analysis in human epidermis, using primers from CYP2C18 and CYP2C19, revealed products containing combinations between canonically defined exons of these two genes. The major RNA species identified contained 2C18 exon 8 spliced with 2C19 exon 2. However, the terminal exons 1 and 9 were never detected in any of these composite molecules. When similar experiments were performed with liver RNA, exons 1 and 9 of both 2C18 and 2C19 were readily identified in composite 2C18/2C19 RNAs. Moreover, molecules containing 2C9 sequences spliced with 2C18 exons were also detected. These findings suggest that during the process of RNA splicing of the 2C transcripts, various exon juxtaposition events may occur, including combinations between exons of distinct genes. However, the frequency of these events is quite low and the levels of the composite RNA molecules are generally estimated at less than one molecule per cell. Since the order of these genes on chromosome 10q24 is CYP2C18 - CYP2C19 - CYP2C9, it is conceivable that the composite RNAs may result from multiple canonical and inverse splicing events of a long pre-mRNA that encompasses the three genes. However, these molecules could also be rationalized as being the products of trans splicing phenomena between distinct pre-mRNAs.
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